B P Koirala Institute of Health Sciences, Nepal
Posters & Accepted Abstracts: J Nephrol Ther
Background: Preeclampsia (PE) is a multisystem disorder of unknown etiology and is characterized by development of hypertension to the extent of 140/90 mm Hg or more with proteinuria after the 20th week in a previously normotensive and nonproteinuric woman. This study was done to compare and evaluate the diagnostic efficiency of serum Cystatin-C, Creatinine and Uric Acid levels in PE and Normal pregnant women. Materials & Methods: This is a hospital based comparative cross-sectional study conducted in BPKIHS. One hundred and two study participants who provided the written consent were enrolled; of which fifty one participants were diagnosed cases of PE and fifty one served as Control. Serum Cystatin-C was done by Immunoturbidimetry method in Accent 200 Autoanalyser. Creatinine and Uric Acid was done by Jaffe├ó┬?┬?s and Uricase method in cobas c311 Autoanalyser respectively. ROC curve was used to evaluate the diagnostic efficiency of Cystatin-C in PE. P-value<0.05 was considered to be significant. Results: Mean Cystatin-C level and UA was significantly increased in PE compared to control group (1.15├?┬▒0.37 v/s 0.55├?┬▒0.12 and 5.40├?┬▒1.44 v/s 3.97├?┬▒0.68 respectively. ROC curve depicted that Cys-C had the highest diagnostic efficiency (Sensitivity-88.24%; Specificity-98.04%) compared to creatinine and UA in PE. Inference: Cystatin-C level is significantly raised in PE compared to traditional renal markers (Creatinine and Uric Acid). Hence, it can detect an early and minimal change in renal function, thereby help in taking early preventive measures and impede the progression of Preeclampsia to Eclampsia.