Cyclopentenes for anti-tuberculosis and antibiotics

Medicinal Chemistry

ISSN: 2161-0444

Open Access

Cyclopentenes for anti-tuberculosis and antibiotics

6th World Congress on Medicinal Chemistry and Drug Design

June 07-08, 2017 Milan, Italy

Hadia Almahli and Stephen P Fletcher

University of Oxford, UK

Posters & Accepted Abstracts: Med Chem (Los Angeles)

Abstract :

In this presentation the author will describe the asymmetric additions of alkyl nucleophiles to racemic allylic chlorides, to access important cyclopentene containing natural products. These natural products have timely biological activity and the eventual synthesis of derivatives will help develop structure-activity relationships. Cyclopentene natural products Alepric acid (1), aleprestic acid (2), and gorlic acid (3) have not previously had their synthesis reported. The asymmetric addition reaction is a dynamic kinetic asymmetric transformation (DYKAT) to a racemic allylic chloride to give cyclopentenes with high level of ee.

Biography :


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