Clinical and histopathological characteristics of patients with glomerulonephritis syndrome in Dar es Saalam, Tanzania

Journal of Nephrology & Therapeutics

ISSN: 2161-0959

Open Access

Clinical and histopathological characteristics of patients with glomerulonephritis syndrome in Dar es Saalam, Tanzania

3rd World Kidney Congress

October 08-10, 2018 Dubai, UAE

Paschal Ruggajo and Amira Deng

Muhimbili University of Health and Allied Sciences, Tanzania

Scientific Tracks Abstracts: J Nephrol Ther

Abstract :

Background: The histologic pattern of specific glomerulopathies and their related clinical presentation and varies according to age, sex, race, socioeconomic status and geographic location. The underlying histopathological pattern of patients presenting with glomerulonephritis syndrome in Tanzania is virtually unknown. Objective: This study was set to determine different clinicolaboratory and histopathological patterns of glomerulonephritis syndrome in Dar es Salaam, Tanzania. Patients & Methods: Hospital based descriptive cross sectional study, all adults from (18 years and above) with proteinuria and hematuria who underwent renal biopsy from April 2017-December 2017 were consecutively recruited into this study. Patients infected with HIV, hepatitis B virus and hepatitis C virus was excluded due to resources constraints. Results: 55 participants with glomerulopathies were enrolled for this study, but 40 were eligible for percutaneous renal biopsy. Two-thirds of participants were female (67.5%) with mean age (±SD) of 32.7 (9.8) years. The commonest lesions were focal segmental glomerulosclerosis (32.2%), followed by minimal change disease (20.0%) and membranous nephropathy (17.5%). Membranoproliferative glomerulonephritis, IgA nephropathy and lupus nephritis were about (5.0%) respectively. Among others histologic findings were renal amyloidosis was about (5.0%), inconclusive findings (10.0%) and undetermined due to excessive fibrosis (1%). Conclusion: Primary glomerulopathies in Tanzania occur more commonly among young (<40 year) female patients presenting with glomerulonephritis syndrome. Focal Segmental Glomerulosclerosis (FSGS) is the most common primary glomerulopathy. There is considerable heterogeneity in the histologic spectrum of glomerulopathies which is influenced by age and gender factors.

Biography :

Paschal Joseph Ruggajo the Vice Presient of Nephrology Society of Tanzania ( NESOT) , member of International Society of Nephrology ( ISN) , Head of Department of Internal Medicine (MUHAS/MAMC) Chairman-Committee for Renal Policy and SoPs (MUHAS/MNH) 2017 Standards Operating Procedures for Nephrology and Kidney Transplant MNH/MoH, He was awarded with Best Workers award in Internal Medicine,MUHAS in 20154, Best Post Graduate Resident Internal Medicine,MUHAS in 2009, Current Research programmes are Low Birth weight and the risk of progressive in Kidney Disease



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