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Medicinal Chemistry

ISSN: 2161-0444

Open Access

Catalytic asymmetric synthesis of biologically active natural products


International Conference on Stereochemistry

August 18-19, 2016 Sao Paulo, Brazil

Takumi Watanabe

Institute of Microbial Chemistry -BIKAKEN, Japan

Scientific Tracks Abstracts: Med chem

Abstract :

Catalytic asymmetric synthesis of caprazamycin B an anti-tuberculosis natural product, and a key synthetic intermediate for scytophycin C a cytotoxic marine natural product, was completed. In order to furnish the key stereochemical elements, both syntheses employed the catalytic asymmetric reactions developed by Shibasaki and coworkers: thioamide-aldol reaction, antiselective nitroaldol reaction, and alcoholysis of 3-methylglutaric anhydride, namely.

Biography :

Takumi Watanabe obtained Master degree from The University of Tokyo, and joined Institute of Microbial Chemistry as a Researcher in 1993. Then, he received PhD degree in 2000, and was promoted to the laboratory Head of Laboratory for Synthetic Organic Chemistry at the same Institute in 2015. He joined ETH as a Post-doctoral fellow (Prof. Erick M. Carreira) from 2002 to 2004.

Email: [email protected]

Information

Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To cite this article:


Received Date: Jan 01, 1970
Accepted Date: Jan 01, 1970
Published Date: Jan 01, 1970

 
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