Institute of Microbial Chemistry -BIKAKEN, Japan
Scientific Tracks Abstracts: Med chem
Catalytic asymmetric synthesis of caprazamycin B an anti-tuberculosis natural product, and a key synthetic intermediate for scytophycin C a cytotoxic marine natural product, was completed. In order to furnish the key stereochemical elements, both syntheses employed the catalytic asymmetric reactions developed by Shibasaki and coworkers: thioamide-aldol reaction, antiselective nitroaldol reaction, and alcoholysis of 3-methylglutaric anhydride, namely.
Takumi Watanabe obtained Master degree from The University of Tokyo, and joined Institute of Microbial Chemistry as a Researcher in 1993. Then, he received PhD degree in 2000, and was promoted to the laboratory Head of Laboratory for Synthetic Organic Chemistry at the same Institute in 2015. He joined ETH as a Post-doctoral fellow (Prof. Erick M. Carreira) from 2002 to 2004.
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Jan 01, 1970
Accepted Date: Jan 01, 1970
Published Date: Jan 01, 1970