Associations of sex hormone binding globulin and free testosterone concentration in postmenopausal women with type 2 Diabetes Mellitus

Priya D Alva

K.S Hegde Medical Academy, India

Posters & Accepted Abstracts: Altern Integr Med

Abstract :

Introduction: Sex Hormone Binding Globulin (SHBG) is a glycoprotein secreted by the liver into the bloodstream. The principal function of SHBG is to transport the sex steroids mainly androgen and estrogen. Hyper insulinemia and insulin resistance is thought to play an important role in the inhibition of SHBG there by increasing the androgen concentration leading to hyper androgenicity.

Aim: To find the association of SHBG and free testosterone levels in postmenopausal women with type 2 diabetes mellitus.

Research design and methods: It is a case control study. 105 postmenopausal women with type 2 diabetes mellitus and 85 control subjects were recruited from the outpatient department of K.S Hegde Charitable Hospital, Deralakatte, Mangalore. Anthropometric variables, SHBG, steroid hormones, insulin and the degree of insulin resistance were measured among case and control women.

Results: Women with type 2 diabetes mellitus had significantly higher insulin [21.4 (3.02, 30.9 μIU/mL) p value<0.001), lower SHBG [20.65 (12.54, 33.46 nmol/l)]p value<0.05 and higher free testosterone [0.0245 (0.011, 0.03nmol/l) p value<0.05 than the control. SHBG correlated negatively with insulin, insulin resistance and free testosterone.

Conclusion: Low levels of SHBG are observed in type 2 diabetic postmenopausal women with higher insulin resistance and free testosterone. Thus, reduced SHBG in postmenopausal women with type 2 diabetes mellitus can be correlated with insulin resistance and hyperandrogenecity.

Biography :

Alva has completed her Master degree in Medical Biochemistry from Manipal University in the year 2009. Currently she is a Research Scholar from K.S Hegde Medical Academy, Mangalore.

E-mail: pri2720@gmail.com