Antibodies with functionality as a new generation of translational tools designed to be programmed via translational resources to predict and to prevent demyelination

Joint Event on 5^th Global Summit on Herbals and Traditional Medicine & 11^th World Congress on Precision and Personalized Medicine

August 14-15, 2019 | Auckland, New Zealand

Sergey Suchkov

I.M. Sechenov First Moscow State Medical University, Russia
European Association for Prediction, Prevention and Personalized Medicine, Europe

Keynote: Altern Integr Med

Abstract :

Abs against myelin basic protein/MBP endowing with proteolytic activity (Ab-proteases with functionality) is of great value to monitor demyelination to illustrate the evolution of Multiple Sclerosis (MS). Anti-MBP auto Abs from MS patients and mice with EAE exhibited specific proteolytic cleavage of MBP which, in turn, markedly differed between: (1) MS patients and healthy controls; (2) different clinical MS courses; (3) EDSS scales of demyelination to cor-relate with the disability of MS patients to predict the transformation prior to changes of the clinical course. Ab-mediated proteolysis of MBP was shown to be sequence-specific whilst demonstrating five sites of preferential proteolysis to be located within the immune-dominant regions of MBP and to fall inside into 5 sequences fixed. Some of the latter (with the highest encephalitogenic properties) were proved to act as a specific inducer of EAE and to be at-tacked by the MBP-targeted Ab-proteases in MS patients with the most severe (progradient) clinical courses. The other ones whilst being less immunogenic happened to be EAE inducers very rare but were shown to be attacked by Ab-proteases in MS patients with moderate (re-mission-type) clinical courses. The activity of Ab-proteases was first registered at the sub-clinical stages 1-2 years prior to the clinical illness. About 24% of the direct MS-related rela-tives were seropositive for low-active Ab-proteases from which 22% of the seropositive rela-tives established were being monitored for 2 years whilst demonstrating a stable growth of the Ab-associated proteolytic activity. Moreover, some of the low-active Ab-proteases in per-sons at MS-related risks (at subclinical stages of MS), and primary clinical and MRT mani-festations observed were coincided with the activity to have its mid-level reached. Registra-tion in the evolution of highly immunogenic Ab-proteases would illustrate either risks of transformation of subclinical stages into clinical ones, or risks of exacerbations to develop. The activity of Ab-proteases in combination with the sequence-specificity would confirm a high subclinical and predictive (translational) value of the tools as applicable for personalized monitoring protocols. Ab-proteases can be programmed and re-programmed to suit the needs of the body metabolism or could be designed for the development of principally new catalysts with no natural counterparts. Further studies on targeted Ab-mediated proteolysis may provide a translational tool for predicting demyelination and thus the disability of the MS patients.

Biography :

Sergey Suchkov has completed his Graduation from Astrakhan State Medical University and was awarded with MD. He has completed PhD from I.M. Sechenov Moscow Medical Acad-emy and Institute of Medical Enzymology. He is currently a Professor, Director and Center for Personalized Medicine, I.M. Sechenov First Moscow State Medical University and De-partment of Clinical Immunology, A.I. Evdokimov Moscow State Medical and Dental Uni-versity; and Professor, Chair, Department for Translational Medicine, Moscow Engineering Physical Institute, Russia and also Secretary General, United Cultural Convention, UK.

E-mail: ssuchkov57@gmail.com