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Uremic Cardiomyopathy | Open Access Journals
Journal of Interventional and General Cardiology

Journal of Interventional and General Cardiology

ISSN: 2684-4591

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Uremic Cardiomyopathy

Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD). In dialysis patients, sudden cardiac death accounts for 40% of all deaths. In these patients, sudden cardiac death is generally secondary to an underlying cardiomyopathy, which is clinically identified by the high prevalence of left ventricular hypertrophy and the resulting mechanical and electrical dysfunction. CRI-related cardiomyopathy has a multifactorial pathophysiology. Recent evidence has highlighted the central pathophysiological role of chronic kidney disease - mineral and bone disorders (CKD-MBD) with hyperphosphatemia and high levels of fibroblast growth factor 23 (FGF23) in these patients. In addition, as CKD is known to be αKlotho deficient, experimental studies have shown that the deleterious effects of FGF23 can be minimized by restoring adequate soluble Klotho levels. Here, we present a review that not only addresses the development of understanding of the pathophysiology of CKD-related cardiomyopathy, but also explores recent data that identifies the triad of hyperphosphatemia, elevated levels of FGF23 and deficiency in αKlotho as playing a central role in this regard. Together, the data suggests that uremic cardiomyopathy can be seen as a new piece of the CKD-BMD puzzle.

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Citations: 11

Journal of Interventional and General Cardiology received 11 citations as per Google Scholar report

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