Tuberculous Involvement Of The Central Nervous System

Tuberculosis of the central nervous system (CNS) is a very devastating form of tuberculosis which, even with appropriate anti-tuberculosis treatment, leads to unacceptable levels of morbidity and mortality. Despite the development of promising molecular diagnostic techniques, the diagnosis of CNS tuberculosis is largely based on insensitive microbiological methods and, as such, CNS tuberculosis remains a formidable diagnostic challenge. Information on the basic neuropathogenesis of Mycobacterium tuberculosis and the development of an appropriate animal model is desperately needed. The optimal regimen and duration of therapy are largely unknown, and with the increasing incidence of multidrug-resistant strains of M. tuberculosis, the development of well-tolerated and effective antibiotics remains a constant need. While the most widely used vaccine in the world largely targets this manifestation of tuberculosis, the BCG vaccine has not kept its promise of eliminating tuberculosis from the CNS. We propose this review to highlight the current understanding of the neuropathogenesis of M. tuberculosis, to discuss certain epidemiological, clinical, diagnostic and therapeutic aspects of CNS tuberculosis, and also to highlight the many unmet needs in this important area.

High Impact List of Articles

Conference Proceedings

Bilateral pulmonary embolism after arthroscopic anterior cruciate ligament reconstruction: A case report
Nawaf Alogayyel,Raheef Alatassi and Saeed Koaban
Scientific Tracks Abstracts: Journal of Clinical Case Reports
Bilateral pulmonary embolism after arthroscopic anterior cruciate ligament reconstruction: A case report
Nawaf Alogayyel,Raheef Alatassi and Saeed Koaban
Scientific Tracks Abstracts: Journal of Clinical Case Reports
Synchronous ipsilateral clear cell renal cell carcinoma and chromophobe renal cell carcinoma: A case report and review of literature
Anila Chughtai
Scientific Tracks Abstracts: Journal of Clinical Case Reports
Synchronous ipsilateral clear cell renal cell carcinoma and chromophobe renal cell carcinoma: A case report and review of literature
Anila Chughtai
Scientific Tracks Abstracts: Journal of Clinical Case Reports
Psychometric investigation and measurement of hunger and pleasure
Dale M Hilty
Posters & Accepted Abstracts: Journal of Advanced Practices in Nursing
Psychometric investigation and measurement of hunger and pleasure
Dale M Hilty
Posters & Accepted Abstracts: Journal of Advanced Practices in Nursing
The effects of education through multimedia and text messaging on the psychological parameters of patients scheduled for coronary angiography
Camellia Torabizadeh
Posters & Accepted Abstracts: Journal of Advanced Practices in Nursing
The effects of education through multimedia and text messaging on the psychological parameters of patients scheduled for coronary angiography
Camellia Torabizadeh
Posters & Accepted Abstracts: Journal of Advanced Practices in Nursing
All hands on Edward: Integrating a skills laboratory within a pediatric emergency department
Daniela Ricci and Diana Gomez
Posters & Accepted Abstracts: Journal of Advanced Practices in Nursing
All hands on Edward: Integrating a skills laboratory within a pediatric emergency department
Daniela Ricci and Diana Gomez
Posters & Accepted Abstracts: Journal of Advanced Practices in Nursing

Clinical Infectious Diseases: Open Access