Total Knee Arthroplasty

Total knee replacement surgery (TKP) or total knee replacement surgery (TKR) is an orthopedic surgical procedure where the joint surfaces of the knee joint (the femoral condyles and the tibial plateau) are replaced. There is at least one piece of polyethylene, placed between the tibia and the femur, as a shock absorber. In 50% of cases, the patella is also replaced. Reasons for replacing the patella include: osteolysis, poor tracking of the patella, implant failure. The goal of reconstructing the patella is to restore the extensor mechanism. The level of bone loss will dictate the type of patellar prosthesis placed. When all of the knee compartments are damaged, a total knee replacement may be necessary. The most common reason for a total knee replacement is osteoarthritis. Osteoarthritis causes the cartilage in the joint to be damaged and can no longer absorb shock. There are many external risk factors that can cause osteoarthritis of the knee. For example: being overweight; previous knee injuries; partial removal of a meniscus; rheumatoid arthritis; fractures; congenital factors. Certain genetic factors may also contribute to the development of osteoarthritis, but more research is needed. Total knee replacement is more commonly performed on women and the incidence increases with age. In the United States in 2008, 63% of TKR's operations involved women.

High Impact List of Articles

Conference Proceedings

GP referral process for isotretinoin treatment in moderate to severe acne
Munther Zureigat, Judy Mullan, Jo-Ann See and Andrew Booney
Scientific Tracks Abstracts: Journal of General Practice
GP referral process for isotretinoin treatment in moderate to severe acne
Munther Zureigat, Judy Mullan, Jo-Ann See and Andrew Booney
Scientific Tracks Abstracts: Journal of General Practice
Role of genetic testing in lung transplantation
Rolando Grave de Peralta Menendez
Posters & Accepted Abstracts: Pulmonary & Respiratory Medicine
Role of genetic testing in lung transplantation
Rolando Grave de Peralta Menendez
Posters & Accepted Abstracts: Pulmonary & Respiratory Medicine
A novel serum microrna panel to discriminate benign from malignant ovarian disease
Ream Langhe
Posters & Accepted Abstracts: Cancer Science & Therapy
A novel serum microrna panel to discriminate benign from malignant ovarian disease
Ream Langhe
Posters & Accepted Abstracts: Cancer Science & Therapy
Identifying the border of cutaneous squamous cell carcinoma by targeted EGFR antibodies conjugated to gold nanoparticles
Asaf Olshinka
Scientific Tracks Abstracts: Cancer Science & Therapy
Identifying the border of cutaneous squamous cell carcinoma by targeted EGFR antibodies conjugated to gold nanoparticles
Asaf Olshinka
Scientific Tracks Abstracts: Cancer Science & Therapy
Diagnostic and prognostic value of UHRF1 in breast cancer patients
Feng Yan
Accepted Abstracts: Cancer Science & Therapy
Diagnostic and prognostic value of UHRF1 in breast cancer patients
Feng Yan
Accepted Abstracts: Cancer Science & Therapy

Journal of Surgery