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Journal of Clinical Case Reports

Journal of Clinical Case Reports

ISSN: 2165-7920

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Tau Pathology Scientific Journals

The pathway from the soluble, monomeric tau protein to the insoluble, filamentous hyperphosphorylated tau protein is central to many human neurodegenerative diseases, collectively known as tauopathies. The dominant hereditary mutations of MAPT, the gene that codes for tau, cause forms of frontotemporal dementia and parkinsonism, proving that dysfunction of tau is enough to cause neurodegeneration and dementia. However, most cases of tauopathy are not inherited predominantly. The first aggregates of tau form in a few nerve cells in discrete areas of the brain. These spread automatically and spread to distant brain regions in a prion-like fashion. Preventing the aggregation and spread of tau is central to attempts to develop mechanism-based treatments for tauopathies.

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Citations: 1345

Journal of Clinical Case Reports received 1345 citations as per Google Scholar report

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