GET THE APP
Serous Ovarian Cancer | Open Access Journals
Journal of Cancer Clinical Trials

Journal of Cancer Clinical Trials

ISSN: 2577-0535

Open Access
Spanish Chinese Russian German French Japanese Portuguese Hindi Telugu Tamil
Submit Manuscript arrow_forward arrow_forward ..

Serous Ovarian Cancer

Epithelial ovarian cancer (EOC) is a lethal gynecologic disease that imposes significant burden on health care and patient quality of life. High‐grade serous carcinoma of the ovary (HGSC) is the most prevalent histologic type of EOC. A vast majority of HGSC cases are identify at late stages of the disease, limiting the opportunity for clinical intervention and resulting in a 10‐year survival rate of <20%. Recent innovations in high‐throughput molecular analysis of patient‐derived specimens may address these clinical challenges by providing an enhanced understanding of the molecular aetiology of ovarian cancer, in addition to offering several opportunities for rational biomarker and targeted therapy discovery. In this review, we highlight the most significant contributions of omics approaches and how the advent of immunomics can aid in personalized combination chemo‐immunotherapy in ovarian cancer treatment. We further provide insights into immunogenomic correlates of pre‐treatment tumour immune microenvironment and some of the potential interpretations of immunomic data that require further validation, based on stromal and immune contributions to biomarker signatures. We believe a comprehensive integrative approach via meta‐analysis of large ovarian cancer molecular profiling data sets is urgently needed to define robust prognostic and predictive classifiers of disease progression and treatment response. These investigations will inform rationalized biomarker‐driven combination chemo‐immunotherapy trials for improving response and survival of ovarian cancer patients.

High Impact List of Articles
Conference Proceedings

Relevant Topics in Clinical Sciences

Awards & Nominations

50+ Million Readerbase

Journal Highlights

Google Scholar citation report
Citations: 95

Journal of Cancer Clinical Trials received 95 citations as per Google Scholar report

Citation image
Journal of Cancer Clinical Trials peer review process verified at publons
Publon image

Indexed In

Related Links

 

Open Access Journals

arrow_upward arrow_upward