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Journal of Cancer Clinical Trials

ISSN: 2577-0535

Open Access

F Morano


Italy

Publications
  • Commentary
    Osteopontin Expression and its Potential Role as Prognostic Factor and Therapeutic Target for Gastric Cancer
    Author(s): F Morano and M Di BartolomeoF Morano and M Di Bartolomeo

    A correlation between the over expression of Osteopontin (OPN), E-cadherin, β-catenin, and cyclooxygenase 2 and poor prognosis has been previously suggested in solid tumors. The aim of the ITACA-S translational study was to further investigate the correlation of these immunohistochemical biomarkers with the outcome of radically resected gastric cancer patient. The immunohistochemistry expression of osteopontin, E-cadherin, β-catenin, and cyclooxygenase 2 was detected in 346 primary gastric tumor tissue samples from patients enrolled in the ITACA-S trial which randomized patients to receive adjuvant chemotherapy with ether 5-fluorouracil and leucovorin or a sequential regimen of infusional 5-fluorouracil and leucovorin plus irinotecan followed by cisplatin and docetaxel. A higher expression of OPN was associated to diffuse histotype, high grade and peritoneal relapse, but not.. Read More»

    Abstract PDF

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