The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders—autism, schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched controls. We identified patterns of shared and distinct gene-expression perturbations across these conditions. The degree of sharing of transcriptional dysregulation is related to polygenic (single-nucleotide polymorphism–based) overlap across disorders, suggesting a substantial causal genetic component.
Past Conference Report: Journal of Pediatric Neurology and Medicine
Past Conference Report: Journal of Pediatric Neurology and Medicine
Case Report: Journal of Pediatric Neurology and Medicine
Case Report: Journal of Pediatric Neurology and Medicine
Case Report: Journal of Pediatric Neurology and Medicine
Case Report: Journal of Pediatric Neurology and Medicine
Commentary: Journal of Pediatric Neurology and Medicine
Commentary: Journal of Pediatric Neurology and Medicine
Commentary: Journal of Pediatric Neurology and Medicine
Commentary: Journal of Pediatric Neurology and Medicine
Posters & Accepted Abstracts: Neurological Disorders
Posters & Accepted Abstracts: Neurological Disorders
Posters & Accepted Abstracts: Neurological Disorders
Posters & Accepted Abstracts: Neurological Disorders
Posters & Accepted Abstracts: Journal of Spine
Posters & Accepted Abstracts: Journal of Spine
Scientific Tracks Abstracts: Journal of Spine
Scientific Tracks Abstracts: Journal of Spine
Posters & Accepted Abstracts: Neurological Disorders
Posters & Accepted Abstracts: Neurological Disorders
Journal of Pediatric Neurology and Medicine received 68 citations as per Google Scholar report
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