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Rhabdoid Carcinoma Review Articles | Open Access Journals
Journal of Pediatric Neurology and Medicine

Journal of Pediatric Neurology and Medicine

ISSN: 2472-100X

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Rhabdoid Carcinoma Review Articles

Pulmonary tumors with rhabdoid characteristics, included as variants of large cell carcinoma in the classification of lung tumors by the World Health Organization of 1999, are rare and have an aggressive clinical course. We report 11 patients with primary lung tumors with rhabdoid characteristics and review the literature on this rare tumor. We examined samples from 7 primary samples (6 resections, 1 biopsy) and 4 samples from metastatic tumors. All samples were stained with immunohistochemical stains for pancytokeratin (CK), cytokeratin 7 (CK7), cytokeratin (CK20), thyroid transcription factor 1 (TTF-1) and vimentin. The patients were 7 men and 4 women whose ages align from 35 to 70 years. Nine patients had respiratory symptoms and 9 patients had a history of heavy smoking. One patient had a TNM stage I tumor, 3 had stage III tumors and 6 had stage IV tumors at presentation; the tumor stage could not be determined in 1 patient. Histological examination of these tumors showed typical rhabdoid cells: large cells with an abundant cytoplasm, a large eccentric nucleus with a central macronucleolus and a rounded eosinophilic cytoplasmic inclusion which sometimes caused nuclear indentation. These cells make up 10% to 90% of the tumor.

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Citations: 68

Journal of Pediatric Neurology and Medicine received 68 citations as per Google Scholar report

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