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Human Genetics & Embryology

Human Genetics & Embryology

ISSN: 2161-0436

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Preeclampsia Journals

Preeclampsia is a complication of pregnancy recognized by recent-onset gestational hypertension and proteinuria (see definitions below). The disorder affects both mothers and their babies. Once the disease is clinically evident, it can only be cured through childbirth. In developed countries, monitoring of preeclampsia through prenatal care allows for early identification and intervention through delivery. This management has changed little in the last 100 years, and is very effective in reducing maternal mortality. However, maternal morbidity remains excellent with preeclampsia, which remains one of the leading causes of admission of pregnant women to intensive care units in the developed world.1 Furthermore, fetal mortality and morbidity are considerable, related to the effects of the disease. both in the fetus and in prematurity. The indicated delivery of women to prevent the progression of pre-eclampsia is responsible for 15% of all preterm births.2 In developing countries, where inadequate prenatal care limits surveillance of pre-eclampsia, maternal mortality is common, accounting for 50 000 deaths annually.3 Hypertensive disorders of pregnancy include hypertension that precedes pregnancy, chronic hypertension, and gestational hypertension that occurs only during pregnancy. When gestational hypertension is accompanied by recent onset proteinuria, the disorder is called preeclampsia and, when not associated with proteinuria, transient hypertension of pregnancy. If the woman with chronic hypertension also shows evidence of preeclampsia, it is classified as chronic hypertension with overlapping preeclampsia. Eclampsia is the onset of seizures in women with preeclampsia. These criteria have been extremely helpful in helping to recognize pregnant women at risk. The greatest risk to mother and baby is present with preeclampsia, and the risk of chronic hypertensive pregnancy is primarily with overlapping preeclampsia. However, attention to hypertension has, for many years, limited research attention primarily to the mechanisms of hypertension. This was not helpful. In the past 2 decades, the appreciation that preeclampsia is a multisystem syndrome characterized by vasoconstriction, metabolic changes, endothelial dysfunction, activation of the coagulation cascade, and increased response

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