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Astrophysics & Aerospace Technology

Astrophysics & Aerospace Technology

ISSN: 2329-6542

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Pharmacogenomics Related Articles

This basic review of genetic principles will help pharmacists prepare for their possible role in translating gene-drug associations into clinical practice. Genes, which are segments of deoxyribonucleic acid (DNA) contained in 23 pairs of human chromosomes, determine the size and shape of each protein that a living organism builds. The variation in pharmacogens that code for proteins central to drug action and toxicity serves as the basis for pharmacogenomics (PGx). Important online resources such as PharmGKB.org, cpicpgx.org and PharmVar.org provide clinicians with organized and summarized PGx associations and clinical guidelines. As genetic testing becomes more affordable and accessible, the time has come for pharmacists to adopt the selection and dosage of PGx-guided drugs to personalize and improve the safety and effectiveness of pharmacotherapy. We are at a crossroads in medical science and pharmacy practice where specific variations in the genetic code are associated with differences in response to drugs, an individual's propensity to develop certain side effects of drugs and variation in the rate and extent of drug metabolism. Called pharmacogenomics (PGx), this new discipline is the study of the interaction between the human genome and the science of pharmacology

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