Ichthyosis vulgaris is caused by mutations in the loss of function of the filaggrin gene (FLG) and is characterized clinically by xerosis, flaking, keratosis pilaris, hyperlinear palmar and plantar and a strong association with atopic disorders https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.12219. According to the published studies presented in this review article, FLG mutations are observed in approximately 7 • 7% of Europeans and 3 • 0% of Asians, but seem to be infrequent in populations with dark skin. This clinical review article provides an overview of the epidemiology of common ichthyosis, associated disorders and pathologicalhttps://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.12219 mechanisms. Not only does ichthyosis vulgaris have a broad clinical spectrum, but recent studies suggest that carriers of FLG mutations may have a generally altered risk of developing common diseases, even beyond atopic disorders. Mechanistic studies have shown increased penetration of allergens and chemicals into filaggrin deficient skin, and epidemiological studies have revealed higher levels of hand eczema, irritant contact dermatitis, nickel sensitization and levels Vitamin D serum levels. If appropriate, individuals should be informed of an increased risk of developing dermatitis when they are repeatedly or continuously exposed to nickel or irritants. In addition, with our current knowledge, people with ichthyosis vulgaris should be protected from neonatal exposure to cats to prevent atopic dermatitis and should refrain from smoking to prevent asthma. Finally, they should be advised against excessive exposure to factors that decrease the skin barrier functions and increase the risk of atopic dermatitis.
Peer Review Journals on Ichthyosis Vulgaris
Editorial: Clinical Infectious Diseases: Open Access
Editorial: Clinical Infectious Diseases: Open Access
Review Article: Clinical Infectious Diseases: Open Access
Review Article: Clinical Infectious Diseases: Open Access
Short Communication: Clinical Infectious Diseases: Open Access
Short Communication: Clinical Infectious Diseases: Open Access
Posters & Accepted Abstracts: Journal of AIDS & Clinical Research
Posters & Accepted Abstracts: Journal of AIDS & Clinical Research
Accepted Abstracts: Journal of AIDS & Clinical Research
Accepted Abstracts: Journal of AIDS & Clinical Research
Scientific Tracks Abstracts: Journal of Advanced Practices in Nursing
Scientific Tracks Abstracts: Journal of Advanced Practices in Nursing
Scientific Tracks Abstracts: Journal of Advanced Practices in Nursing
Scientific Tracks Abstracts: Journal of Advanced Practices in Nursing
Scientific Tracks Abstracts: Journal of Advanced Practices in Nursing
Scientific Tracks Abstracts: Journal of Advanced Practices in Nursing
Clinical Infectious Diseases: Open Access received 1149 citations as per Google Scholar report