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Journal of Bioanalysis & Biomedicine

Journal of Bioanalysis & Biomedicine

ISSN: 1948-593X

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Paget Disease Peer Journal

Pigmented breast Paget's disease is a rare variant of breast Paget's disease that clinically and dermoscopically simulates melanoma. We report a case of pigmented mammary Paget's disease imitating a melanoma and describe the microscopic, histological and confocal immunohistochemical dermoscopic and reflection modes.
 A 70-year-old woman had a 5.5 × 4 cm pigmented plaque with a thin, scaly surface on her left breast; the plaque had slowly but gradually increased over the previous 10 years. Dermoscopic examination showed diffuse, light brown pigmentation with irregular black dots, small gray-blue structures and irregular vessels. Confocal microscopic features, such as large reflective cells with dark nuclei propagating upward pagetoidally, were suggestive of melanoma. The histological evaluation integrated into the immunohistochemical staining showed pigmented mammary Paget's disease.
This case demonstrates that the diagnosis of pigmented mammary Paget's disease cannot be determined by clinical examination and dermoscopy alone. Therefore, immunohistochemical staining should be performed in growing lesions with equivocal clinical and dermoscopic features characterized by abundant pagetoid infiltration in hematoxylin-eosin stained sections to avoid neglecting pigmented mammary Paget's disease.
pigmented breast Paget's disease that was difficult to diagnose despite the use of advanced non-invasive diagnostic techniques such as dermoscopy and confocal microscopy in in vivo reflection mode (CMR), which have been shown to improve accuracy of the diagnosis in dermatological oncology.

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Citations: 3099

Journal of Bioanalysis & Biomedicine received 3099 citations as per Google Scholar report

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