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Journal of Bioanalysis & Biomedicine

Journal of Bioanalysis & Biomedicine

ISSN: 1948-593X

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Paget Disease Open Access Journals

Paget's disease is a chronic, high-turnover focal bone disease that is mainly present in middle-aged and older adults. It appears to be limited to humans and has no clear parallels to other diseases. Although much has been learned about its pathology and epidemiology, and the treatment is now very effective, we still do not have a complete understanding of its etiology and biology. This review focuses on the natural history of the disease, in particular its epidemiological evolution, recent discoveries on its genetic basis and current approaches to diagnosis and treatment. Although there is strong evidence of a genetic predisposition to Paget's disease, there is also convincing evidence that it is becoming less common, the age of patients at presentation increases and that the extent of skeletal impairment decreases, which implies that there is an environmental factor still unknown in its etiology. Contemporary patients are generally elderly and have few bones involved. Treatment with potent intravenous bisphosphonates provides prolonged remission and many will require only once in lifelong treatment.

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Citations: 3099

Journal of Bioanalysis & Biomedicine received 3099 citations as per Google Scholar report

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