Paget Disease Journals

Paget's disease of the bone is a common bone disorder characterized by disorganized bone turnover. The most likely etiology is a slow paramyxoviral infection in genetically sensitive individuals; however, the exact cause is unknown. Improved bone resorption due to increased osteoclast activity recruits many osteoblasts at the resorption sites, which produces large amounts of new bone matrix. Accelerated resorption and bone formation are not as tightly coupled as in healthy bone; disorganized bone tissue forms. Many patients are asymptomatic; the increase in serum alkaline phosphatase or the incidental discovery of characteristic radiographic lesions are often the only diagnostic clues. Common clinical manifestations include bone pain, curvature of long bones, enlargement of the skull, and hearing loss. Elevated serum alkaline phosphatase levels correlate with disease activity. The diagnosis is confirmed by characteristic radiographic results and by a nuclear bone scan (the most sensitive test). Bisphosphonates, such as zoledronic acid, pamidronate, alendronate and risedronate, are the mainstay of treatment. Patients who cannot tolerate bisphosphonates may be treated with calcitonin.

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Conference Proceedings

A prescription for improvement: Health and safety measures
Abdeen Omer
Posters & Accepted Abstracts: Journal of Formulation Science & Bioavailability
A prescription for improvement: Health and safety measures
Abdeen Omer
Posters & Accepted Abstracts: Journal of Formulation Science & Bioavailability
A brief review: Potential pharmacological activity of dipotassium trioxohydroxytetrafluorotriborate, K₂[B₃O₃F₄OH]
Mladen Milos, Maja Marasovic, Sinisa Ivankovic, Ranko Stojkovic, Safija Herenda and Jelena Ostojic
Posters & Accepted Abstracts: Pharmaceutical Regulatory Affairs: Open Access
A brief review: Potential pharmacological activity of dipotassium trioxohydroxytetrafluorotriborate, K₂[B₃O₃F₄OH]
Mladen Milos, Maja Marasovic, Sinisa Ivankovic, Ranko Stojkovic, Safija Herenda and Jelena Ostojic
Posters & Accepted Abstracts: Pharmaceutical Regulatory Affairs: Open Access
The novel suppression of function mutation in the cardiac RyR2 channel presents an allosteric dosedependent effect mechanism
Yulia Einav
Scientific Tracks Abstracts: Journal of Bioanalysis & Biomedicine
The novel suppression of function mutation in the cardiac RyR2 channel presents an allosteric dosedependent effect mechanism
Yulia Einav
Scientific Tracks Abstracts: Journal of Bioanalysis & Biomedicine
Alpha ENaC-b as a gene therapy in salt-sensitive hypertension
Marlene Shehata, Fady Youssef and Alan Pater
Scientific Tracks Abstracts: Journal of Bioanalysis & Biomedicine
Alpha ENaC-b as a gene therapy in salt-sensitive hypertension
Marlene Shehata, Fady Youssef and Alan Pater
Scientific Tracks Abstracts: Journal of Bioanalysis & Biomedicine
Development of sustained release tablet of verapamil HCl using natural polymers
T. A. Mullani, D. A. Bhagwat, A. K. Mullani and J. I. D?Souza
Posters: Pharmaceutical Regulatory Affairs: Open Access
Development of sustained release tablet of verapamil HCl using natural polymers
T. A. Mullani, D. A. Bhagwat, A. K. Mullani and J. I. D?Souza
Posters: Pharmaceutical Regulatory Affairs: Open Access

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Citations: 3099

Journal of Bioanalysis & Biomedicine received 3099 citations as per Google Scholar report

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Journal of Bioanalysis & Biomedicine