Osteoporotic Spine Innovations
Osteoporosis has become a major medical problem as the world's aging population grows rapidly. Osteoporosis predisposes patients to fractures, progressive spinal deformities and stenosis, and is a major concern before performing spine surgery, especially with bone fusions and instruments. Osteoporosis has often been considered a contraindication for spine surgery, while in some cases patients have undergone limited and inadequate procedures to avoid concomitant instrumentation.
Current treatments for osteoporosis have focused on stopping the activity of osteoclastic cells. In particular, the treatment of osteoporosis has focused on the administration of drugs called "anti-resorptive agents" or ARBs. The most common classes of anti-resorptive drugs include estrogens, selective estrogen receptor modulators (SERMs), biphosphonates, calcitonin, osteoprotegrin (OPG), cathespine K and statins. Current products include FOSAMAX® (alendronate) in the United States, Biphosphonate DIDRONEL® (etidronate) and ACTONEL® (risedronate).
As the population ages and the expectations of older patients increase, the demand for surgical treatment in older patients with osteoporosis and degenerative diseases of the spine becomes progressively greater. Today, advances in surgical and anesthetic technology make it possible to operate successfully on elderly patients who no longer accept disabling physical conditions. This article discusses the biomechanics of the osteoporotic spine, the diagnosis and management of osteoporotic patients with the spine, as well as new treatments, recommendations, surgical indications, strategies and instrumentation in patients with osteoporosis who need spine operations.
High Impact List of Articles
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Antidiabetic and Antioxidant Activity of Rubus apetalus Poir. and Rubus steudneri Schweinf. Leaf Extract on Alloxan Induced Diabetes Mellitus
Raghavendra HL, Shivaleela P. Upashe, David Rafael Abreu Reyes and Juliana F. Floriano Research Article: Journal of Bioanalysis & Biomedicine
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Antidiabetic and Antioxidant Activity of Rubus apetalus Poir. and Rubus steudneri Schweinf. Leaf Extract on Alloxan Induced Diabetes Mellitus
Raghavendra HL, Shivaleela P. Upashe, David Rafael Abreu Reyes and Juliana F. Floriano Research Article: Journal of Bioanalysis & Biomedicine
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Spectrophotometric Determination of Sertaconazole Nitrate in Pharmaceutical Dosage Form using Quality by Design (QbD) Framework
Sagar Suman Panda, Sarwar Beg, Ravi kumar Venkata Varaha Bera and Aruneema Gain Research Article: Journal of Bioanalysis & Biomedicine
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Spectrophotometric Determination of Sertaconazole Nitrate in Pharmaceutical Dosage Form using Quality by Design (QbD) Framework
Sagar Suman Panda, Sarwar Beg, Ravi kumar Venkata Varaha Bera and Aruneema Gain Research Article: Journal of Bioanalysis & Biomedicine
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Development and Validation of a UPLC-MS/MS Assay for Simultaneous Estimation of Raloxifene and its Metabolites in Human Plasma
D. H. Jadhav and C. S. Ramaa Research Article: Journal of Bioanalysis & Biomedicine
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Development and Validation of a UPLC-MS/MS Assay for Simultaneous Estimation of Raloxifene and its Metabolites in Human Plasma
D. H. Jadhav and C. S. Ramaa Research Article: Journal of Bioanalysis & Biomedicine
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PEGylated Versus Non-PEGylated γFe2O3@Alendronate Nanoparticles
Benyettou F, Hardouin J, Lecovey M, Jouni H and Motte L Research Article: Journal of Bioanalysis & Biomedicine
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PEGylated Versus Non-PEGylated γFe2O3@Alendronate Nanoparticles
Benyettou F, Hardouin J, Lecovey M, Jouni H and Motte L Research Article: Journal of Bioanalysis & Biomedicine
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A Note on the Calculation of Intrasubject Coefficient of Variation in Bioequivalence Trails
Mahmoud Abdel Mohsen Research Article: Journal of Bioanalysis & Biomedicine
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A Note on the Calculation of Intrasubject Coefficient of Variation in Bioequivalence Trails
Mahmoud Abdel Mohsen Research Article: Journal of Bioanalysis & Biomedicine
Conference Proceedings
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ENDOLIFT and Ultherapy® for the best face, neck and body non-surgical lifting
Dell’Avanzato Roberto Posters & Accepted Abstracts: Journal of Bioanalysis & Biomedicine
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ENDOLIFT and Ultherapy® for the best face, neck and body non-surgical lifting
Dell’Avanzato Roberto Posters & Accepted Abstracts: Journal of Bioanalysis & Biomedicine
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Callus induction in Marigold-Nemo Mix (Tagetespatula L) required for diesel toxicity evaluation
Wante, S.P and Leung, D. W. M Posters & Accepted Abstracts: Journal of Bioprocessing & Biotechniques
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Callus induction in Marigold-Nemo Mix (Tagetespatula L) required for diesel toxicity evaluation
Wante, S.P and Leung, D. W. M Posters & Accepted Abstracts: Journal of Bioprocessing & Biotechniques
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Cell line development for the production of biosimilar monoclonal antibodies with high target bioactivity and high productivity
Noelle Sunstrom, Angelo Perani, Sarah McCaig, Caroline Ferrari, Brendan Broome and Adrian Cawley Posters & Accepted Abstracts: Journal of Bioanalysis & Biomedicine
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Cell line development for the production of biosimilar monoclonal antibodies with high target bioactivity and high productivity
Noelle Sunstrom, Angelo Perani, Sarah McCaig, Caroline Ferrari, Brendan Broome and Adrian Cawley Posters & Accepted Abstracts: Journal of Bioanalysis & Biomedicine
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Quality system controls for clinical trial development and conduct
Lee Truax-Bellows Accepted Abstracts: Pharmaceutical Regulatory Affairs: Open Access
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Quality system controls for clinical trial development and conduct
Lee Truax-Bellows Accepted Abstracts: Pharmaceutical Regulatory Affairs: Open Access
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ICH Q10: Pharmaceutical quality system
Sandeep Kanna and N. Vishal Gupta Posters: Pharmaceutical Regulatory Affairs: Open Access
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ICH Q10: Pharmaceutical quality system
Sandeep Kanna and N. Vishal Gupta Posters: Pharmaceutical Regulatory Affairs: Open Access
Relevant Topics in Pharmaceutical Sciences