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Osteonecrosis Scholarly Peer-review Journal | Open Access Journals
Journal of Biomedical Systems & Emerging Technologies

Journal of Biomedical Systems & Emerging Technologies

ISSN: 2952-8526

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Osteonecrosis Scholarly Peer-review Journal

Osteonecrosis is a bone death caused by poor blood supply. It is more common in the hip and shoulder, but can affect other large joints such as the knee, elbow, wrist, and ankle. Osteonecrosis occurs when part of the bone does not receive blood and dies. After a while, the bone may collapse. If osteonecrosis is left untreated, the joint deteriorates, leading to severe arthritis. Osteonecrosis can be caused by illness or by serious trauma, such as a fracture or dislocation, which affects the blood supply. bone. Osteonecrosis can also occur without trauma or illness. This is called idiopathic - which means that it occurs with no known cause.

Vascular osteonecrosis (VNA) is a bone complication that indicates a poor functional prognosis. Modern immunosuppressive drugs and steroid-sparing drugs have significantly reduced the frequency of AVN after kidney transplantation (KT). However, present data on its incidence rates and risk factors are needed. Using a large recent cohort, we sought to study the incidence of SVA and risk factors, with a particular focus on mineral and bone disorders.   In the group with post-KT AVN, the median time intervals between KT and 1) first symptoms and 2) diagnosis of AVN were 12 months  and 20 months, respectively. Overweight / obesity, pre-transplant diabetes or hyperparathyroidism during transplantation, development of acute rejection and receiving higher cumulative doses of corticosteroids were associated with the occurrence of AVN. Multivariate analysis revealed that BMI ≥ 26 kg / m2 and higher cumulative doses of corticosteroids were predictive of AVN. In overall overweight / obesity is a strong risk factor for AVN. Despite a low maintenance dose, the use of corticosteroids mainly for the treatment of acute rejection remains an independent risk factor.

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Citations: 43

Journal of Biomedical Systems & Emerging Technologies received 43 citations as per Google Scholar report

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