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Electro Chemotherapy | Open Access Journals
Medicinal Chemistry

Medicinal Chemistry

ISSN: 2161-0444

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Electro Chemotherapy

When a sufficiently large electric field is applied to a tissue for an adequate duration, transmembrane voltage is induced across the cell plasma membrane. As a result, the changes within the geometrical and material properties of the tissue cause local deficiencies within the cell wall and make it permeable to agents that otherwise could not transfer into it. This phenomenon is usually known as electroporation (EP). There are two types of EP: reversible and irreversible. The duration of the pulses and field intensity determine whether the structural changes within the cell wall are reversible, allowing cells to survive or irreversible, resulting in cell death because of the loss of homeostasis.

 

This phenomenon became a standard technique for loading cells with materials that are either impossible or difficult to undergo the cells. This led to the expansion of EP-based technology for biomedical applications and researches within the field of drug delivery and gene therapy, like gene electrotransfection, nonthermal irreversible electroporation, and electrochemotherapy (ECT). Recently National Institute for Health and Care Excellence (NICE) in UK suggests ECT to manage inaccessible or otherwise difficult to treat primary Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) in carefully selected patients.

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Medicinal Chemistry received 6627 citations as per Google Scholar report

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