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Clinical Presentation Of CNS Tuberculoma | Open Access Journals
Clinical Infectious Diseases: Open Access

Clinical Infectious Diseases: Open Access

ISSN: 2684-4559

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Clinical Presentation Of CNS Tuberculoma

The clinical presentation of CNS tuberculoma is generally more subtle than that of tuberculous meningitis and may include headache, seizures, focal neurologic deficits, and papillary edema. Tuberculosis accompanies tuberculous meningitis in 10% of patients and is multiple in a third of patients. Lesions can occur in the brain, spinal cord, subarachnoid, subdural or epidural space; they can be solitary but are most often multiple and accompanied by a surrounding edema and an improvement of the ring. In children, the lesions tend to be infratentorial, while in adults they are generally supratentorial. At CT, tuberculomas are characterized as masses of low or high density and rounded or lobulated and show an intense homogeneous or annular improvement after administration of the contrast. They have an irregular wall of varying thickness. Moderate to marked perilesional edema is frequently present. Tuberculosis can be single or multiple and is more common in the frontal and parietal lobes, usually in the parasagittal areas. At CT, the target sign, a central calcification or nidus surrounded by a ring that improves after administration of the contrast, is considered to be pathognomonic of the tuberculoma.

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