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Journal of Cancer Clinical Trials

Journal of Cancer Clinical Trials

ISSN: 2577-0535

Open Access
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Cancer Genes Open Access Journals

Hereditary cancer is estimated to account for up to 10% of the worldwide cancer burden and breast cancer is one of the top cancers with a large proportion (10-15%) of hereditary cases. Many cancer-predisposing genes are involved in the balance between cell growth and cell death or in maintaining genome integrity. There are about 500 known cancer-causing genes with reported mutations in somatic and/or germline DNA. Of those genes about 100 have been shown to be mutated in germline DNA of human and could be inherited from parents to their children and predispose them to hereditary cancers. Among genes which are associated with inherited cancers and BRCA1, BRCA2, CHEK2, PALB2 and NBS1. Identification of predisposing mutations enables specific management including prevention, early detection and treatment. Cancers that arise in mutation carriers usually have specific clinical characteristics, prognosis and sensitivity to treatment.

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Citations: 95

Journal of Cancer Clinical Trials received 95 citations as per Google Scholar report

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