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Bioconjugation | Open Access Journals
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Chemical Sciences Journal

ISSN: 2150-3494

Open Access

Bioconjugation

Bioconjugation is a chemical strategy in which two molecules, at least one of which is a biomolecule, form a stable covalent bond between. Synthetically modified biomolecules can have a variety of functionalities, such as revealing enzyme function, determining the biodistribution of proteins, delivering drugs to target cells and imaging specific biomarkers. Bioconjugation is a key technique for connecting these modified biomolecules to different substrates. The most popular bioconjugations are the combination of a small molecule (such as biotin or fluorescent dye) to a protein, or non-protein conjugations, such as the combination of an antibody to an enzyme. Some less common bioconjugation molecules are oligosaccharides, nucleic acids, synthetic polymers like polyethylene glycol, and carbon nanotubes. Examples of bioconjugation are also antibody-drug conjugates such as Brentuximab vedotin and Gemtuzumab ozogamicin, and are an active research area in the pharmaceutical sector. Bioconjugation has also recently gained interest in applications of nanotechnology such as bioconjugated quantum dots.

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