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Best Peer Review Articles On Pharmacodynamics | Open Access Journals
Pharmacoeconomics: Open Access

Pharmacoeconomics: Open Access

ISSN: 2472-1042

Open Access
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Best Peer Review Articles On Pharmacodynamics

Pharmacodynamics follow the logic of cause and consequence. Receptor-mediated and reversible effects can be distinguished from direct and irreversible effects. Reversible effects are capacity-limited and saturable whereas irreversible effects are limited only by the number of viable targets. In the case of receptor-mediated and reversible effects a threshold and a ceiling concentration are often defined. Concentration-dependent effects are related to a high ceiling concentration and therefore the target is that the high peak. Time-dependent effects are related to a high threshold concentration and therefore the target is that the high trough. Kidney dysfunction influences the pharmacokinetic parameters of a minimum of 50% of all essential drugs. Clinicians usually consider pharmacokinetics when renal disorder is found, but pharmacodynamics is as important. Alterations of pharmacodynamic parameters are conceivable but only rarely reported in kidney failure. Sometimes surprising dosing adjustments are needed when pharmacodynamic concepts are brought into the choice process of which dose to settle on. Pharmacokinetics and pharmacodynamics should both be considered when any dosing regimen is decided. The response of the receptor could also be suffering from the presence of medicine competing for an equivalent receptor, the functional state of the receptor or pathophysiological factors like hypokalaemia. Interindividual variability in pharmacodynamics could also be genetic or reflect the event of tolerance to the drug with continued exposure. These biomarkers are crucial in gaining insight into disease mechanisms for first-in-class drugs with a completely unique non validated mechanism of action.

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Citations: 106

Pharmacoeconomics: Open Access received 106 citations as per Google Scholar report

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