GET THE APP

Androgen Receptor Phosphorylation | Open Access Journals

Journal of General Practice

ISSN: 2329-9126

Open Access

Submit Manuscript

Androgen Receptor Phosphorylation

Reactivation of androgen receptor (AR) may drive recurrent prostate cancer in castrate patients. Ack1 phosphorylates AR at Tyr-267 and potentially Tyr-363, both in the N-terminal transactivation area. In this examination, the job of these phosphorylation destinations was researched by portraying the phosphorylation site freaks with regards to full length and shortened AR without the ligand-restricting area. Y267F and Y363F freaks indicated diminished transactivation of journalists. Articulation of wild kind full length and shortened AR in LNCaP cells expanded cell multiplication in androgen-exhausted conditions and expanded settlement development. Be that as it may, the Y267F freak of full length and shortened AR was blemished in animating cell expansion. The Y363F freak was less seriously influenced than the Y267F freak. The full length AR Y267F freak was inadequate in atomic translocation incited by androgen or Ack1 kinase. The shortened AR was constitutively restricted to the core. Chromatin immunoprecipitation investigation indicated that it was selected to the objective enhancers without androgen.

High Impact List of Articles

A Prospective Medical System of the Future/a Complete Health Care System
Mahdy Ali Ahmad Osman
Review Article: Journal of General Practice
A Prospective Medical System of the Future/a Complete Health Care System
Mahdy Ali Ahmad Osman
Review Article: Journal of General Practice
African American Childhood and Adolescent Obesity: Interventions with Group Therapy
Arthur Horton
Short Communication: Journal of General Practice
African American Childhood and Adolescent Obesity: Interventions with Group Therapy
Arthur Horton
Short Communication: Journal of General Practice
Which Motivational Factors are of More Relevance to the Rural Health Worker? Evidence from a Ghanaian District Hospital
Emmanuel Kumah
Research Article: Journal of General Practice
Which Motivational Factors are of More Relevance to the Rural Health Worker? Evidence from a Ghanaian District Hospital
Emmanuel Kumah
Research Article: Journal of General Practice
Stories Notebook about the Fundamental Concepts in Family Medicine: An Introduction
Jose Luis Turabian
Short Communication: Journal of General Practice
Stories Notebook about the Fundamental Concepts in Family Medicine: An Introduction
Jose Luis Turabian
Short Communication: Journal of General Practice
The Clinical Challenge of Opioid-induced Constipation: Insights from the Opioid-induced Constipation Clinical Audit
Peter Katelaris and George Krassas
Research Article: Journal of General Practice
The Clinical Challenge of Opioid-induced Constipation: Insights from the Opioid-induced Constipation Clinical Audit
Peter Katelaris and George Krassas
Research Article: Journal of General Practice

Conference Proceedings

A simple clinical prognosis tool to predict mortality after a first hospitalization for COPD
Alain Vanasse, J Courteau, S Couillard S, M F Beauchesne M F and P Larivee
Posters & Accepted Abstracts: Pulmonary & Respiratory Medicine
A simple clinical prognosis tool to predict mortality after a first hospitalization for COPD
Alain Vanasse, J Courteau, S Couillard S, M F Beauchesne M F and P Larivee
Posters & Accepted Abstracts: Pulmonary & Respiratory Medicine
The important overlapping problem between malign and benign thyroidal nodules in cancer patients with FDG-PET/CT
Fikri Sekcuk Simsek and Yavuz Narin
Scientific Tracks Abstracts: Cancer Science & Therapy
The important overlapping problem between malign and benign thyroidal nodules in cancer patients with FDG-PET/CT
Fikri Sekcuk Simsek and Yavuz Narin
Scientific Tracks Abstracts: Cancer Science & Therapy
Anti-cholesterol activity, in vivo test and the toxicity test of multifunction herbs
Dewi Tristantini and Diana Christina
Posters & Accepted Abstracts: Alternative & Integrative Medicine
Anti-cholesterol activity, in vivo test and the toxicity test of multifunction herbs
Dewi Tristantini and Diana Christina
Posters & Accepted Abstracts: Alternative & Integrative Medicine
BTK modulates p53 activity to enhance apoptotic and senescent responses
Mohammad Althubiti
Posters & Accepted Abstracts: Cancer Science & Therapy
BTK modulates p53 activity to enhance apoptotic and senescent responses
Mohammad Althubiti
Posters & Accepted Abstracts: Cancer Science & Therapy
Sensitivity of direct smear microscopy for the diagnosis of TB in high HIV prevalent population Nnewi, Nigeria
Uzoewulu Ngozi G1, Ibeh I N2, Ofiaeli R O1, Umenyonu N3 and Okonkwo R1
Posters-Accepted Abstracts: Pulmonary & Respiratory Medicine
Sensitivity of direct smear microscopy for the diagnosis of TB in high HIV prevalent population Nnewi, Nigeria
Uzoewulu Ngozi G1, Ibeh I N2, Ofiaeli R O1, Umenyonu N3 and Okonkwo R1
Posters-Accepted Abstracts: Pulmonary & Respiratory Medicine
Physiotherapy and research: Instruments validation
Ines Llamas-Ramos
Keynote: Journal of Physiotherapy & Physical Rehabilitation
Physiotherapy and research: Instruments validation
Ines Llamas-Ramos
Keynote: Journal of Physiotherapy & Physical Rehabilitation

Relevant Topics in Medical Sciences

Google Scholar citation report

Citations: 1047

Journal of General Practice received 1047 citations as per Google Scholar report

Journal of General Practice peer review process verified at publons

Indexed In

Related Links

Open Access Journals