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Journal of Nephrology & Therapeutics

ISSN: 2161-0959

Open Access

Current Issue

Volume 10, Issue 3 (2020)

    Volume 11, Issue 9 (2021)

      Editorial Note Pages: 1 - 2

      Renal Transplantation and Enterocystoplasty

      Lucy Lu

      Renal transplantation acts novel difficulties in youngsters like the authoritative treatment of end stage renal infection. The supply of kidneys,
      surgical technical challenges, immunosuppression treatment, development and improvement, and social contemplations entangle
      the administration of end stage renal infection in kids. Also, youngsters have a higher affinity of basic lower urinary parcel anomalies
      contrasted with the grown-up with procured renal infection. The writing is dubious in the conversation of the standardization of the
      urinary plot brokenness previously during or after transplantation. Be that as it may, the need and timing of the expansion stay unanswered.

      Brief Report Pages: 1 - 3

      Low Rate of Adequacy of Percutaneous Kidney Biopsy Associated with Lack of On-site Microscopic Examination

      Randah Abdullah Dahlan1*, Guzaiz Noha H2 and Almarwni Abdulhakim A1

      Background and objectives: Renal biopsy is an essential diagnostic tool used by nephrologists to establish the diagnosis of many glomerular diseases. The
      absence of an adequate biopsy sample may affect the course of management of patients who may suffer from a serious underlying disease requiring an early
      initiation of therapy. We conducted a quality improvement project aiming to assess the rate of adequate percutaneous native kidney biopsy samples in the absence
      of on-site microscopic examination of samples. Furthermore, the project also aimed to study the effect of some variables on the adequacy rate.
      Methods: We included all percutaneous native kidney biopsies performed between January 1, 2017, and December 31, 2020. We excluded allograft renal biopsies
      from this study. Data were retrospectively collected; and included: patient-related data, procedure-related data, and biopsy results-related data. The sample was
      labeled as adequate if at least ten glomeruli were seen on light microscopy, and at least one glomerulus on immunofluorescence and one glomerulus on electron
      microscopy. Biopsies not fulfilling the aforementioned criteria were labeled as inadequate.
      Results: Out of 82 percutaneous native kidney biopsies, 35 biopsies (43%) were adequate and the remaining 47 biopsies (57%) were inadequate. When
      comparing the adequate versus the inadequate group we found that the age, gender, weight, BMI, operator, needle size, number of passes, and the number of
      cores were the same in both groups.
      Conclusion: Our study demonstrates the high rate of inadequate renal biopsy samples associated with the lack of on-site microscopic examination of samples.
      Age, gender, weight, BMI, operator, needle size, number of passes, and number of cores did not affect the rate of the adequacy. The small sample size represents
      a limitation of this study.

      Research Article Pages: 1 - 9

      The Association between Serum Indoxyl Sulfate, P-Cresyl Sulfate and Cardiovascular Risk Factors in Peritoneal Dialysis Patients

      Aschalew Fikru Hiruy1, Qianqian Xiong1, Xiaolei Guo1, Li Li1, Qiman Jin1, Jing Zhao1, Xuechun Lin1, Shuiqing He1, Chenjiang Ying1,3, and Xuezhi Zuo2*

      Background: Indoxyl Sulfate (IS) and p-Cresol Sulfate (pCS) are two important gut-derived uremic toxins accumulated in patients with Chronic Kidney Disease
      (CKD). They have been reported contributing greatly to Cardiovascular Disease (CVD) both in epidemiological studies and animal models. The present study was
      conducted to explore whether IS and pCS contribute to CVD by accelerating cardiovascular risk factors in Peritoneal Dialysis (PD) patients.
      Methods: A cross-sectional study was conducted on 119 PD patients. Serum IS and pCS were measured by Ultra-High-Performance LC–tandem MS (UPLCMS/
      MS), and metabolic parameters involved in cardiovascular risk were measured by auto-biochemistry analyzer machine. Univariate and multivariate linear
      regression models were performed to determine the association between the independent variables (IS and pCS) and clinical indexes. Multivariable-adjusted
      logistic regression models were used to estimate the odds ratios (ORs, 95% confidence intervals (CIs)).
      Results: The median BMI of PD patients was 20.10 (18.95, 22.90) kg/m2. The median serum IS and pCS concentrations were 22.46 (13.45, 29.92) mg/L
      and 12.41 (5.29, 24.45) mg/L, respectively. Positive significant associations were observed between serum IS concentration and PD duration, creatinine, prealbumin,
      phosphorus, magnesium and β2-microglobulin (β2-m) with the corresponding correlation coefficient r and p value of 0.22 (P=0.020), 0.48 (P<0.001),
      0.32 (P<0.001), 0.34 (P<0.001), 0.28 (P=0.002), 0.50 (P<0.001). Also, statistically negative significant associations were observed between IS and estimated
      Glomerular Filtration Rate (eGFR)-0.46 (P<0.001). Besides, a significant positive association between pCS and albumin 0.32 (P<0.001) was indicated.
      Conclusions: Serum clinical indexes were dependent cardiovascular risk factors for increasing IS and pCS levels, which contribute to CVD in peritoneal dialysis
      patients. Mechanism research should be conducted in the future to explore causality.

      Short Communication Pages: 1 - 2

      Radical Prostatectomy in Kidney Transplant Recipients with Prostate Cancer

      Marnia Ihekaikie

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      Close urologic follow-up of renal transplant candidates and beneficiaries frequently uncovers prostate carcinoma at a beginning phase. Two
      patients who went through renal transplantation for end-stage illness additionally went through revolutionary perineal prostatectomy for limited
      prostate carcinoma, 3 years subsequent to uniting in 1 patient and 4 years prior to joining in the other. The perineal way to deal with
      prostatectomy might work with later renal transplantation and stay away from allograft harm.

      Editorial Pages: 1 - 2

      Renal Dysfunction and the Advanced Chronic Heart Failure

      Marnia Ihekaikie

      Patients with advanced Chronic Heart Failure (CHF) are inclined to decrease renal capacity due to poor renal perfusion and abundance
      vasoconstriction. The intense administration of patients with decompensated CHF is frequently muddled by worry for precipitating deteriorating
      renal capacity. Despite the fact that diuretics and Angiotensin-Converting Enzyme Inhibitors (ACEIs) work on cardiovascular yield and for the
      most part work on renal perfusion in patients with decompensated CHF, a few patients have deteriorating of renal capacity. When
      aggravated renal dysfunction does occur, doses of ACEIs and diuretics are often reduced or with held in an attempt to preserve renal
      function. This training might be improper in patients with diligently raised filling tensions and low cardiovascular yield. Exasperated renal
      dysfunction may in this way drag out the intense therapy period of CHF, defer the help of indications, and result in imperfect dosing of ACEIs—
      specialists with portion subordinate long term good results in CHF.

      Volume 11, Issue 8 (2021)

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Citations: 647

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