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Journal of Genetics and DNA Research

Open Access

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Volume 3, Issue 2 (2019)

    Short Communication Pages: 1 - 1

    PREDICTION OF FOLDING SITES OF ├?┬?├?┬?-TREFOIL PROTEINS WITH IRREGULAR STRUCTURES

    Risako Kimura and Takeshi Kikuchi

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    Details of protein folding mechanism are still unknown. The solution to this problem is useful for elucidating the mechanism and treatment of diseases caused by misfolding.

    Short Communication Pages: 1 - 1

    Solute binding proteins and their cognate ligands: structure, function and their role in functional annotation

    Umesh Yadava

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    The uptake of exogenous solutes is mediated by transport systems embedded in the plasma membrane and drive active transport even at μM to nM solute concentrations. In many of these systems a periplasmic Solute-Binding Protein (SBP) is utilized to bind their cognate ligands with high affinity and deliver them to the membrane bound translocator subunits.

    Short Communication Pages: 1 - 1

    STD-aids in asia and world perspective

    S M Rasel Faruk

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    In 2008, there were an expected 110 million common STIs among ladies and men in the United States. Of these, over 20% of diseases (22.1 million) were among ladies and men matured 15 to 24 years. In 30 unique microscopic organisms, infections, and parasites prompt more noteworthy than 1 million sexually transmitted contaminations every day.

    Short Communication Pages: 1 - 1

    Structural co-evolution of PACAP/GCGR from invertebrates to vertebrates

    B K C Chow

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    Statement of the Problem: G-protein coupled receptors (GPCRs), an essential molecular signaling device to connect extracellular stimulus and intracellular response, are currently one of the major targets for therapeutic drugs

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    Towards high resolution GABAA receptor modular structure

    Hong Xue

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    Type A gamma-butyric acid (GABAA) receptor is the main inhibitory neurotransmitter receptor family in the brain. Previous studies including those by us have associated GABAA receptor structural and functional variations with neuropsychiatric disorders such as schizophrenia.

    Volume 5, Issue 1 (2021)

      Open Access Pages: 1 - 1

      Genetics Engineering

      Rehman Abdul

      Sphingosine-1-phosphate [S1P] is a potent bioactive sphingolipid molecule. In response to a stimulus, S1P is produced intracellularly by the action of two sphingosine kinases, and then it is exported to the extracellular environment or acts as an intracellular second messenger. S1P binds to its cognate G-protein coupled receptors, which are known as S1P receptors. There are five S1P receptors that have been identified in vertebrates. By activating S1P receptors, S1P controls a variety of physiological and pathological processes including cell migration, angiogenesis, vascular maturation, inflammation, and invasion, metastasis, and chemoresistance in cancer. S1P has emerged as a critical regulator of leukocyte migration and plays a central role in lymphocyte egress from the thymus and secondary lymphoid organs. In the current review article, we summarize the current understanding of the emigration of lymphocytes and other leukocytes from bone marrow, thymus and secondary lymphoid organs to the circulation, as well as the clinical implications of modulating the activity of the major S1P receptor, S1PR1. Sphingosine-1-phosphate [S1P] is a sphingolipid metabolite and a potent signalling molecule that regulates diverse cellular processes including cell proliferation, survival, differentiation and migration. Intense research by many groups has provided a comprehensive understanding of the role of S1P signalling in diverse physiological processes. These include but are not limited to metazoan and mammalian development, reproduction, angiogenesis, vascular maturation

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