Journal of Integrative Oncology

ISSN: 2329-6771

Open Access

Current Issue

Volume 10, Issue 8 (2021)

    Editorial Pages: 1 - 1

    A Priori Activation of Apoptosis Pathways of Tumor (AAAPT) Technology Using Natural Tumor Sensitizers for Treatment Of Triple Negative Breast Cancer Patients

    Raghu Pandurangi

    Statement of the Problem: Cancer cells have inherent ability to circumvent intervention irrespective of the nature of intervention by desensitizing themselves through a) activating survival pathways (e.g. NF-kB, PARP) and downregulating cell death pathways (e.g. CD95, ASK1) simultaneously. The situation is worse for triple negative breast cancer (TNBC) patients who have no option except non-specific chemotherapy, despite high off-target toxicity. No targeted therapy is approved for TNBC treatment since TNBC lack biomarkers (e.g. PR, ER and HER2 negative) for which drugs are designed. This puts TNBC patients on an enormous risk for survival. The purpose of this study is to make FDA approved drugs better using AAAPT technology.

    Short Communication Pages: 1 - 1

    Role of Post Mastectomy Radiotherapy in T1, T2 Lesions With 1-3 Positive Axillary Lymph Nodes Study Of 101 Cases

    Nikhil Garg

    Background: Post mastectomy radiotherapy (PMRT) reduces loco-regional recurrence (LRR) and improves overall survival.There is international consensus to recommend PMRT for patients with tumour size more than 5 cm, tumour invasion of the skin, pectoral muscle or chest wall and patients with > 4 positive lymph nodes. However, the role of PMRT for patients with T1 , T2 disease with 1â??3 positive LN is still controversial. The side effects of radiotherapy and its associated morbidity have to be considered in the risk benefit ratio, thus difficult to arrive at consensus in early breast cancer. Methods: 101 patients treated between 2012 to 2015 were studied retrospectively, The inclusion criteria for this analysis were:(1) Female patients with unilateral breast cancer and no distant metastasis at initial diagnosis who underwent mastectomy and axillary lymph node dissection; (2) postoperative pathology indicated T1â??2 and 1â??3 positive axillary lymph nodes (T1â??2N1M0) disease, at least 10 lymph nodes removed by axillary dissection; (3) complete surgical resection of the tumor and negative margins; (4) complete estrogen receptor (ER), progesterone receptor (PR) and human epithelial growth factor receptor family 2 (Her2) status; (5) No neoadjuvant chemotherapy was administered before surgery and endocrine therapy was performed based on the hormone receptor status. In order to study the research questions, we formulated hypotheses as follows,1. Radiotherapy does not have any impact on recurrence post mastectomy.2. There is no influence of Peri nodal extension on recurrence. The above hypotheses were tested using chi- square test. Results: Recurrences were obtained in 9 amongst radiotherapy and without radiotherapy in 16.When chi square was applied ,the value was highly significant. Hence our hypothesis was rejected. Also in case of PNE with recurrence and radiotherapy,8 had PNE with radiotherapy and recurrence and 27 had no recurrence, p value was 0.013% hence highly significant. Conclusions: Radiotherapy should be strongly considered in patients with 1-3 nodes post mastectomy as it decreases the chances of recurrence
    Short Communication Pages: 1 - 1

    Transition Metal Complexes/Organometallic Compounds as Anticancer/Anti HIV Drugs Or in Pharmaceutical Industry

    Prakash Kinthada

    Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Research on Platinum based drugs and Non-Platinum based drugs is a Multi-Million Dollar Industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoids, belonging to a group of flavonol, Curcumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers. Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic preparations in Indian System of medicine.

    Short Communication Pages: 1 - 1

    Secondary Breast Cancer Diagnosis May 2015 to the Spine And Sacrum

    Ruth Urquhart

    I was first diagnosed with this disease when I was 37 and had hoped that as the 10 year landmark came and went that I was not going to revisit this disease. I was wrong, at the age of 51 I suffered excruciating pain to my spine and was told that my cancer had returned and was now incurable. Previous visits to my GP with my deteriorating back condition had not considered a recurrence of my disease instead the GP thought I was suffering from acute muscle spasms

    Short Communication Pages: 1 - 1

    Genomics versus metabolomics in disease diagnosis

    Subrahmanyam Vangala

    Aim: To study the genomics versus metabolomics in disease diagnosis. This study focuses on metabolomics in disease diagnosis and how a combined genotype-phenotype approach can help in accurate disease diagnosis, especially in the early stages of disease.

    Editorial Pages: 1 - 1

    Editorial - Announcement


    The Journal of Integrative Oncology is a leading research journal dedicated to promote inspiring research outcome to the biological community. This leading-edge, open access journal encompasses diverse fields such as: Clinical and Healthcare Research, Immunology, Stem Cell Research, Genetics, and Medicine in addition to integrative oncology related topics associated with the cancer research. The Journal compiles the latest oncology associated research thereby provides its readers an edge over the others.

    Volume 10, Issue 3 (2021)

      Editorial Pages: 1 - 1

      Oral Health in Oncology Patients and Effects of Radiation

      Sidy KA

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      Editorial Pages: 1 - 1

      Cancer Associated Deficiency Disease

      John A

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      Editorial Pages: 1 - 1

      Radiation Treatment to Contract Tumors and Slaughter Malignancy Cells

      John KA

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      Volume 10, Issue 5 (2021)

        Editorial Pages: 1 - 1

        Dental Problems in Cancer Affected Patients


        Introduction The dentition of head and neck cancer patients is of utmost importance once they receive actinotherapy, particularly as a result of patients reside longer once a course of head and neck radiation. Smart communication among the medicine team members (the radiation and medical oncologists, the external body part prosthodontist/dental medical specialist, ear-nose-and-throat doctor, rehabilitative doctor, nursing support) and therefore the patient is important at first and afterward as well as the overall medical man likewise. The aim of this primer for all those caring for patients with head and neck cancer is to underscore the vital role of the dental medical specialist throughout all phases of actinotherapy, and to supply tips to attenuate and stop dental complications like radiation-induced decay and ORN. Dentures ought to be avoided where doable. Removable prostheses square measure unseen in the dead of night. Oral lubricants/artificial secretion are also applied to the work surface of the dental appliance to enhance comfort and retention once water lessens is gift.

        Editorial Pages: 1 - 1

        Nutrient Deficiency in the Cancer Affected Patients


        What could be a “cancer patient”? A cancer patient is a patient with a cancer diagnosing United Nations agency is either expecting or on cancer-directed treatment, on symptomatic treatment, and/or receiving palliative care. Patients cured from their cancer are termed “cancer survivors”. It vital to grasp that the denomination “cancer patient” is kind of general and can cowl a patient throughout the complete flight of the sickness, together with modern adjuvant, curative, and adjuvant yet as completely different stages of treatment with palliative intent within the case of incurable sickness. Patients at time of diagnosing could also be within the cancer flight any place on its course, and move on it to cure or to palliation; so nutrition treatment ideas might have to be custom-made consequently.

        Editorial Pages: 1 - 1

        Interventional Radiology or Radiation Oncology


        This sort of specialist has practical experience in giving radiation treatment to treat malignancy. A radiation oncologist supervises radiation treatment therapies. They work intimately with other colleagues to build up the treatment plan. Radiation Oncology is a rousing, fulfilling and energizing field with a scope of chances in general society and private zones. It consolidates the best regions of care for patients, everything being equal, with testing and consistently evolving treatment. The day by day work can be intriguing and rousing. Demonstrative radiologists may have particular preparing in explicit fields, like mammography or imaging of the gastrointestinal plot. Radiation oncologists are specialists who have practical experience in utilizing radiation to treat disease. Preparing comprises of at least five years of postgraduate schooling. The main year of postgraduate clinical preparing should be spent in a certify interior medication, family practice, medical procedure, pediatrics, or temporary year program followed by four years of preparing in radiation oncology.

        Editorial Pages: 1 - 1

        Gastro Esophageal Reflux Sickness


        This Thoracic Oncology Division at DHRC involves a specific group of experts who are committed to forestalling, diagnosing, treating, and overseeing cellular breakdown in the lungs and different malignancies of the chest, including disease of the throat, thymus, and mediastinum (the space in the chest between the sacs containing the lungs). The division unites specialists in clinical oncology, radiation oncology, thoracic medical procedure, radiology, pulmonology, and nursing. This specific way to deal with treating thoracic malignancies furnishes patients with the specific sort of administrations they need to fight the infection and its physical, enthusiastic, and social results. Specific thoracic specialists treat lung and esophageal malignancy, while particular cardiovascular specialists treat the heart. Thoracic medical procedure, otherwise called chest medical procedure, might be utilized to analyze or fix lungs influenced by malignant growth, injury or pneumonic illness. In any case, medical procedure is a typical therapy for most thoracic malignancies. Your PCP may likewise suggest: Radiation treatment to contract tumors and slaughter malignancy cells.
        Editorial Pages: 1 - 1

        Oncology Esthetics Supplements Clinical Oncology Medicines


        Oncology feel includes forward-thinking preparing that is explicitly and extraordinarily intended to prepare estheticians in the adjustment of skincare therapies in spas to guarantee the wellbeing of individuals who are in the battle of battling malignancy. Oncology Esthetics includes high level training that is intended to give estheticians the. Information on the best way to change skincare/spa medicines to guarantee a protected result for your skin in the event that you are living. With malignancy. A great many people search for solace and help from the terrible results related with malignancy. Oncology facial therapies is a type of tasteful therapy that is intended to supplement clinical oncology therapy, tending to one of a kind skin worries that can emerge from oncology therapy while additionally offering significant integrative treatment to help lighten pressure and uneasiness related with combatting malignancy.

        Volume 10, Issue 9 (2021)

          Short Communication Pages: 1 - 1

          The Impact of Axillary Limph Node Evaluation On The Prognosis Of Breast Cancer Patients

          J. Eglītis

          Breast cancer is the most common cancer type among women and also the most common cause of cancer related death in women worldwide, including Latvia. During the period from 2009 until 2016, the mortality rates in Latvia have increased from 20,7 to 23,3 per 100,000 inhabitants. Metastatic axillary lymph nodes are one of the important factors predicting prognosis of breast cancer patients. The aim of this study was to determine the effect of the N ratio on patient survival.

          Short Communication Pages: 1 - 1

          Indications, Efficacy and Safety of Chemoport in Children: A Study from a Tertiary Center

          Ami Makwana

          Long term venous access is cumbersome in the pediatric age group due to thinner caliber veins, easy compromisation of venous integrity and less co-operative nature of children. Few studies are available that look at the use of chemoports in children and their complications.

          Short Communication Pages: 1 - 1

          Necrotizing Fasciitis as a Rare Documented Side Effect of Docetaxel

          Jeffry Beta Tenggara

          Docetaxel was frequently used to treat solid tumors, primarily breast cancer by disrupting microtubule function to inhibit cell division. Although this agent was known to cause myalgia, arthralgia and neuropathy, there are few reports since 2005 that published the myositis complication of this agent. We presented a case report of necrotizing fasciitis as a continuing myositis condition that happened after Docetaxel treatment.

          Short Communication Pages: 1 - 1

          Effect of Breakfast Intake on Body Mass Index of Females at One Year after Delivery in Alexandria, Egypt

          Dr. Nermeen El Beltagy

          One hundred postpartum cases with BMI>25 at one year after delivery were matched with one hundred normal weight control mothers for age between January and December 2014. All study participants were interviewed and dietary behavior was assessed using the Snack and Beverage Food Frequency Questionnaire (SBFFQ).Seven days recall of breakfast and snack intake was done. Mothers’ intake of certain sweet and salty items during the prior seven days was assessed by asking how many days, how many times per day, and how much of the item the mother consumes. Finally, the intake was converted into the total calories consumed for each individual item and was summed to obtain the total daily caloric intake.

          Editorial Pages: 1 - 1

          Editorial Announcements


          The Journal of Integrative Oncology is a leading research journal dedicated to promote inspiring research outcome to the biological community. This leadingedge, open access journal encompasses diverse fields such as: Clinical and Healthcare Research, Immunology, Stem Cell Research, Genetics, and Medicine in addition to integrative oncology related topics associated with the cancer research. The Journal compiles the latest oncology associated research thereby provides its readers an edge over the others.

          Editorial Pages: 1 - 1

          Streamlined Genetic Education Is Effective In Preparing Women Newly Diagnosed With Breast Cancer for Decision-Making About Treatment-Focused Genetic Testing: A Randomized Controlled Non-Inferiority Trial

          Bettina Meiser

          Purpose: Increasingly, women newly diagnosed with breast cancer are being offered treatment-focused genetic testing (‘TFGT’). As the demand for TFGT increases, streamlined methods of genetic education are needed. Patients and Methods: In this non-inferiority trial, women aged <50 with either a strong family history (FH+) or other features suggestive of a germline mutation (FH-) were randomized before definitive breast cancer surgery to receive TFGT education either: as brief written materials (intervention group, IG) or during a genetic counseling session at a familial cancer clinic (FCC, usual care group, UCG). Women completed self-report questionnaires at four time points over 12 months.

          Volume 10, Issue 6 (2021)

            Volume 10, Issue 7 (2021)

              Short Communication Pages: 1 - 1

              The Old and the New In Medical Cancer Therapy

              Daniel Gandia

              Medical cancer treatment has evolved in a geometric manner since Gilman´s Mechlorethamine introduction into the bedside. Chemotherapy was born and rapidly proved its worth in different tumors and different clinical settings. Initially, the bright results were seen in hematologic malignancies, namely complete remissions in some types of leukemias and lymphomas and posteriorly in solid tumors, it changed the natural disease history in osteosarcoma, becoming adjuvant methotrexate the new overall survival drug in this malignancy. Many pediatric and young adults’ tumors comported complete remissions with chemotherapy, rendering them as curable diseases. As this, testicular cancer became the first example of a curable cancer model within advanced solid tumors (Cisplatin was the gladiator here). Even when the first clinical trial became from the sixties, during the seventies Oncologists became interested in the after-surgery chemo in breast cancer. Two pivotal trials (the US and Europe), continue showing that even nearly 40 years after, the overall survival benefit of adjuvant chemo in this disease is impressive. As many as with chemo, hormonotherapy proved and continues to prove its worth in postmenopausal breast cancer women. Adding to the before, two milestones in chemo history are the role of chemo in larynx organ preservation and its positive role in the colorectal cancer adjuvant setting. Taking as a profit chemo radio sensitizer power, the role of concomitant chemotherapy and radiotherapy came up to age: Head neck, rectal cancer, anal cancer only to mention some tumor topographies amenable to this combined approach with organ preservation objectives.

              Short Communication Pages: 1 - 1

              Mechanistic Studies on the Anti-Tumor Activities of Omega-3 Polyunsaturated Fatty Acids on the Human Neuroblastoma LA-N-1 Cells

              Leung KN

              Neuroblastoma is the most common extracranial solid cancer among infants and children. The prognosis of patients with advanced stages of neuroblastoma with N-myc amplification remains poor despite intense multimodality therapy, and there is a pressing need for alternative therapeutic strategies. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are naturallyoccurring long-chain fatty acids containing a carbon-carbon double bond at the omega C-3 position. Although previous studies have demonstrated the anti-proliferative effect of n-3 PUFAs on different cancer cell lines in vitro, the anti-tumor effects and underlying molecular action mechanisms of n-3 PUFAs, including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), on human neuroblastoma cells remained poorly understood. In this study, both DHA and EPA were shown to suppress the proliferation of two human neuroblastoma LA-N-1 and SH-SY5Y cell lines in a concentration- and timedependent manner.

              Short Communication Pages: 1 - 1

              Study of Epigenomic Changes (Noncoding -Tag. Oncogene) In Primary Cells of Cancer Patients than Biopsy Cells from Normal Tissue

              Saeed Soroush

              The epigenetic is a set of controlled reversible processes which causes inherited changes in the expression of genes Independent of the change in the nucleotide sequence of DNA. Changes in heterochromatin to yochromatin and vice versa. In DNA Methylation, Histone Modifications are considered as epigenetic mechanisms which regulates target genes in the transcription machine and On the other hand, the interaction of non-coding RNAs like Micro RNAs With target gene has identified their roles in the growth of differentiation and cell death. Therefore, epigenetic factors directly or indirectly change the expression of Micro RNAs in the cell. Certainly failure in these mechanisms leads to activating or inhibiting different messaging pathways and causing diseases such as cancer. As you know, the differentiation and survival of cells occur due to constant gene control patterns that also cancer is created as a result of a change in expression of the activity of carcinogenic genes or tumor suppressor genes. The expression of genes at the DNA and chromatin levels is regulated through epigenetic mechanisms. Of these, some small molecules and drugs that interact with specific sequences of DNA can be modified locally and allow the transcriptional machine to reach the target genes and, ultimately, to change the heterochromatin to the cochromatin, can be mentioned.

              Short Communication Pages: 1 - 1

              Potential of Recombinant Protein (ULLB-0005) in Different Cancer

              Sudeep Kumar

              Recombinant protein (ULLB-0005), is derived from a natural fungal protein, which has high binding specificity toward the carbohydrate antigen (Galβ1–3GalNAc- α-O-Ser/Thr). The natural Amino acid sequence has been modified to make more stable and soluble protein. Modified sequence has been cloned and express in E.coli. The protein was purified through different column chromatography and was characterized as a single protein. The present study evaluated the anticancer activity of Recombinant protein ULLB-0005 by determining in vitro cytotoxicity fingerprint, efficacy, mechanism and safety in human cell lines. Promising cytotoxicity was observed in 9 different cancer cell line, with a good safety profile in human PBMCs. The efficacy of the Molecule as antitumor agent was assessed in respective xenograft immuno-compromised mice models in vivo. As expected the molecule showed strong anticancer activity in immune-compromised mice model in various cancers which was observed in the reduction of tumor volume.

              Short Communication Pages: 1 - 1

              Childhood Cancer - A Silent Killer of Children in Low and Middle-Income Countries

              Syed Azizur Rahman

              Childhood cancer is an emerging health challenge in many developing countries. Globally, an estimated 215,000 children of < 15 years and 85,000 adolescents of 15-19 develop cancer each year, and 80% of them live in developing countries. This population will exceed 90% in the next two decades due to an increasing size of the young population in favor of developing countries. Over 100,000 children die needlessly every year, most without any basic effective pain relief, undiagnosed, misdiagnosed, diagnosed too late or not treatment at all. If diagnosed at an early stage, and if treatment is available, most childhood cancers are highly curable. At least 50% of childhood cancer can be cured by simple treatments. The survival gap between rich and poor countries is widening. The reason is mainly due to the success of pediatric cancer therapy in developed countries. Diagnostic and treatment protocols and high adherence rates in these countries improve childhood cancer survival by 75-80%. However, in low and middle-income countries (LMIC), children are not benefitting from these improvements. Largely, because of abandonment rates are high and there are limited supportive care services to prevent treatment related morbidity or mortality.

              Short Communication Pages: 1 - 1

              The Effect of Sex in the Storage Capacity of Red Blood Cell Concentrates in CPD/SAGM

              Vasileios L Tzounakas

              Statement of the Problem: Red blood cells (RBCs) are the most frequently transfused blood labile product. The “Donorvariation effect”, which refers to donor-todonor differences observed in both blood storage quality and 24h recovery, is probably a key factor in the efficiency of transfusion therapy. Donor variation effect may be associated with genetically determined features of RBCs and plasma. The aim of this study was to examine whether thedonor’s sex may independently affect the storage capacity of donated RBCs. Methodology & Theoretical Orientation: For this purpose, 14 leukoreduced units of RBC concentrates in CPD/SAGM (7 male–7 female) were stored for 42 days at 4-6oC. Several parameters of storage quality (including hemolysis, redox status etc) were examined before and throughout the storage period. SPSS was used for statistical analysis of the results.

              Volume 10, Issue 2 (2021)

                Research Article Pages: 1 - 4

                Brief Facts About Covid-19 (Sars-Cov-2)

                Sorush Niknamian

                Coronaviruses are a group of related viruses that cause diseases in mammals and birds. In humans, coronaviruses cause respiratory tract infections that can
                range from mild to lethal. Mild illnesses include some cases of the common cold, while more lethal varieties can cause SARS, MERS, and COVID-19. The
                outbreak was identified in Wuhan, China, in December 2019, declared to be a Public Health Emergency of International Concern on 30 January 2020, and
                recognized as a pandemic on 11 March 2020. Coronaviruses are the subfamily Orthocoronavirinae, within the family of Coronaviridae, order Nidovirales, and
                realm Riboviria. They are enveloped viruses with a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry. The genome size of
                coronaviruses is approximately from 26 to 32 kilobases. Coronaviruses were first discovered in the 1930s and Human coronaviruses were discovered in the
                1960s. The earliest ones studied were from human patients with the common cold, which were later named human coronavirus 229E and human coronavirus
                OC43. Other human coronaviruses have since been identified, including SARS-CoV in 2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-CoV in 2012, and
                SARS-CoV-2 in 2019. Most of these have involved serious respiratory tract infections

                Opinion Article Pages: 5 - 7

                Ways of informing to reveal the truth about cancer in practice

                Evangelia Michail Michailidou

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                Opinion Article Pages: 8 - 9

                General principles of cancer pain management

                Evangelia Michail Michailidou

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                Short Communication Pages: 10 - 10

                Breast cancer screening barriers from the women??s perspective: A meta-synthesis

                Ahmad Moosavi

                Background: The principal aim of health service providers in the field of breast cancer is to detect and treat lesions at an appropriate time. Therefore, identification of barriers to screening can be very helpful. The present study aimed to systematically review the qualitative studies for extracting and reporting the barriers of screening for breast cancer from the women’s perspective. Materials and Methods: In this systematic review; Pubmed, Google Scholar, Ovid Scopus, Cochrane Library, Iranmedex, and SID were searched using the keywords: screening barriers, cancer, qualitative studies, breast and their Persian equivalents, and the needed data were extracted and analyzed using an extraction table. To assess the quality of the studies, the Critical Appraisal Skills Program me (CASP) tool was used. Results: From 2,134 related articles that were found, 21 articles were eventually included in the study. The most important barriers from the point of view of 1,084 women were lack of knowledge, access barriers (financial, geographical, cultural), fear (of results and pain), performance of service providers, women's beliefs, procrastination of screening, embarrassment, long wait for getting an appointment, language problems, and previous negative experiences. Articles' assessment score was 68.9. Conclusions: Increasing women's knowledge, reducing the costs of screening services, cultural promotion for screening, presenting less painful methods, changing beliefs of health service providers, provision of privacy for giving service, decreasing the waiting time, and providing high quality services in a respectful manner can be effective ways to increase breast cancer screening.

                Short Communication Pages: 11 - 11

                Sonography of the Neoplastic Diseases in the Gastro- Intestinal Tract

                Dr.Vikas Leelavati Balasaheb Jadhav

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