Department of Pediatrics
University of California, San Diego, USA
Dr. Dan Zhou received his doctoral degree in Georg-August University, Goettingen, Germany. He has broad background in biochemistry, molecular biology and genetics. He has been interested in tissue hypoxia and hyperoxia at the cellular and molecular level since 2002. He has been focusing on mechanisms underlying tolerance and adaptation to extreme environments in model organisms as well as in humans. He generated unique Drosophila models that can tolerate extreme oxygen environments and discovered mechanisms that regulate tolerance to hypoxia and hyperoxia, some of these mechanisms are evolutionarily conserved in mammals. In addition, he analyzed the genomes of human subjects living at high altitude and identified genes and pathways that regulate adaptation or maladaptation to high altitude hypoxia. Some of these mechanisms are potential targets for developing novel diagnosis and treatment of clinical conditions at sea level. Dr. Zhou serves as editorial board member for AIMS genetics, and as reviewer for several scientific journals, including Scientific Report and PLoS Journals.
His research is focused on understanding the genetic and molecular mechanisms underlying Hypoxia/Ischemia tolerance and injury as well as the mechanisms regulating tolerance and susceptibility to oxidative stress.