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Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Current Issue

Volume 12, Issue 9 (2020)

    Editor Note Pages: 1 - 0

    Editorial Note for Journal of Cancer Science and Therapy

    Shravan K. Putta

    DOI: 10.37421/jcst.2020.12.e137

    The Journals aims to flourish and to maintain the standards in research and cancer diagnosis, provide platform and opportunity to present research outcome and thus help in promoting Cancer and Oncology research and probably it is much in deed for students, teachers and health care professionals to enhance the patient care.

    Review Article Pages: 1 - 5

    A Review on Merkel Cell Polyomavirus - A Subclinical Infection or a Sinisterical Carcinogen?

    Sasi S. Senga and Jemma Arakelyan

    DOI: 10.37421/jcst.2020.12.638

    Viral infections can be attributed to a significant percentage of the global cancer burden. In this review, we will delve into the principles of the
    molecular mechanism underpinning Merkel cell polyomavirus associated oncogenesis. Merkel cell polyomavirus leads to highly aggressive and
    relatively rare skin cancer known as Merkel cell carcinoma. This virus was first detected in 2008 when it was secluded from tumors of patients with
    Merkel cell carcinoma. The presence of Merkel cell polyoma virus in tumors was confirmed by Southern blot analysis and sequencing. Of the 10
    tumors tested, 8 were positive for virus, confirming a strong association, which led to the WHO IARC classification as a Group 2A, “carcinogenic
    to humans”. There is little evidence which shows the association of Merkel cell polyomavirus and lung cancer. The plethora of diagnostic and
    predictive biomarkers that are evolving alongside therapeutic and preventive strategies for Merkel cell polyomavirus associated cancers and the
    evidence of its role in tumourigenesis.

    Commentary Pages: 1 - 3

    Electronic Nicotine Delivery Systems (ENDS) - Risk Factors and Comorbidities

    Govinda Yadav

    DOI: 10.37421/jcst.2020.12.639

    An electronic cigarette (or e-cig) is a battery-fuelled vaporizer that mirrors tobacco smoking. It works by heating up a nicotine fluid, called "juice." It
    is sold as a more beneficial interchange than conventional cigarettes. Nicotine juice (or e-juice) comes in different flavors and nicotine levels. e-fluid
    is made out of five fixings: vegetable glycerin (a material utilized in a wide range of food and individual consideration items, similar to toothpaste)
    and propylene glycol (a dissolvable most regularly utilized in mist machines.) propylene glycol is the fixing that produces thicker billows of fume.

    Short Communication Pages: 1 - 1

    MicroRNA Expression in Advanced Breast Cancer

    Shravan K. Putta

    DOI: 10.37421/jcst.2020.12.642

    Breast cancer growth is the most widely recognized disease
    influencing females around the world, with in excess of 2
    million new cases analyzed in 2018. In the Middle East and
    North Africa (MENA) locale, bosom disease comprises 31.1%
    of the all out malignant growth rate in females, with a death
    pace of 20.9%. In Algeria, the quantity of cases analyzed in
    2018 arrived at 11847, comprising 24% of the instances of
    malignant growth occurrence among Algerian females in 2018,
    which is a rate a lot higher than the remainder of the MENA
    locale. The middle time of determination was seen as 48, and
    66% of the analyzed Algerian females were underneath the
    age of 50. This age is over 10 years sooner than that of
    Western Europe and the United States of America.

    Short Communication Pages: 1 - 1

    miRNAs in the Treatment of Breast Cancer

    Shravan K. Putta

    DOI: 10.37421/jcst.2020.12.643

    Malignancy is one of the primary driver of death around
    the world, and in the previous decade, many exploration
    examines have concentrated on finding new treatments to
    lessen the symptoms brought about by customary treatments.
    Advancement, microenvironment alteration and required for
    metastatic movement, have been generally examined as
    effective medication conveyance vehicles. Regular cell
    reinforcements and numerous phytochemicals have been as of
    late presented as hostile to malignancy adjuvant treatments
    because of their enemy of proliferative and favorable to
    apoptotic properties. Directed treatment is another part of
    malignant growth treatment targeting focusing on a particular
    site, for example, tumor vasculature or intracellular organelles,
    leaving the environmental factors unaffected. This
    tremendously builds the explicitness of the treatment, lessening
    its downsides.

    Volume 12, Issue 7 (2020)

      Mini Review Pages: 1 - 3

      The Role of PARP Inhibitors in the Treatment of Triple Negative Breast Cancer

      Karima Oualla, Lamiae Nouiakh, Otmane Zouiten, Mohamed Ismaili, lamiae Amaadour, Zineb Benbrahim, Samia Arifi and Nawfel Mellas

      DOI: 10.37421/jcst.2020.12.636

      Triple Negative Breast Cancer (TNBC) is a particular subtype of breast cancer accounting for 15% to 20% of all breast cancer. It is defined on
      immunohistochemistry (IHC) by negative estrogen receptor (ER) and progesterone receptors (PR) and negative human epidermal growth factor
      receptor 2 (HER2) and characterized by aggressive nature, distinct metastatic patterns, lack of targeted therapies and poor outcomes. Cytotoxic
      chemotherapy was the mainstay of treatment for long decades and the development of new treatments for selected patients was complicated
      because of the heterogeneity of TNBC. The good understanding of molecular and genomic mechanisms of TNBC has allowed the development
      of new targeted therapies more efficient. Although the heterogeneity of genetic alterations in TNBCs based on the ethnicity and the age, BRCA
      mutations are found in around 20% to 25% of patients and especially in those of the basal-like immune-phenotype. Thus, targeting the defects
      in the DNA repair pathway becomes a promising field of research for this selected category of TNBC patients. Poly (ADP-ribose) polymerase
      (PARP) inhibitors exploit this DNA defects through synthetic lethality and therefore represent a promising treatment especially in BRCA1/ BRCA2
      mutation carriers. These findings have finally allowed bringing personalized treatment to this orphan disease. In this work we tried to explain the
      rationale and mechanisms of targeting the immune system in TNBC, to report the results from recent clinical trials that put immunotherapy as a
      new standard of care in TNBC.

      Research Article Pages: 1 - 5

      Changing Paediatric Cancer Practice in COVID-19 Times

      Rajendra B. Nerli, Abhilasha Sampagar, Manas Sharma, Shridhar C. Ghagane, Sushant Deole, Pulkit Gupta, Shashank D. Patil and Murigendra B. Hiremath

      DOI: 10.37421/jcst.2020.12.637

      Introduction: Experts dealing with the treatment of cancer in children believe that the COVID-19 pandemic could pose a serious global challenge
      to the delivery of affordable and equitable treatment to children with cancer. In this paper we report our experience in the management of children
      with cancer in these COVID-19 times.
      Patients and Methods: Out-patient case records, in-patient case records, imaging pictures of all children with cancer attending our hospital were
      retrieved and analyzed.
      Results: Our study period extended from Dec 2019 until the end of April 2020. During this period, it was observed that the number of children
      attending the outpatient department, undergoing day-care procedures including chemotherapy, as well as children undergoing surgery progressively
      declined due to COVID-19 associated lockdown. Efforts were made to help the children and their families to gain easy access to treatment.
      Conclusion: COVID-19 has disrupted the world and has caused widespread anxiety among families of children with cancer. The medical fraternity
      with active help from all agencies should work out measures to reduce these difficulties faced by children and their families to provide the means
      to ensure the continuity of curative treatments and palliative care as effectively as possible.

      Volume 12, Issue 8 (2020)

        Editor Note Pages: 1 - 1

        Editorial for Journal of Cancer Science and Therapy

        Shravan K. Putta

        DOI: 10.37421/jcst.2020.12.e138

        The Journals aims to flourish and to maintain the standards in research
        and cancer diagnosis provide platform and opportunity to present recent
        discoveries and developments in the field of cancer research thus help in
        promoting Cancer, Oncology research and so it is much useful for students,
        Researchers and health care professionals to enhance the patient care.

        Research Article Pages: 1 - 4

        Evaluation of Surgical Lymphadenectomy in Management of Cancer Endometrial

        Rehab M. Abdelrahman and Ahmed Y. Abdulkader

        DOI: 10.37421/jcst.2020.12.640

        Treatment for most endometrial cancer patients tends to be surgical. The treatment of choice for complete hysterectomy and bilateral salpingooophorectomy with or without lymphadenectomy has been an open abdominal approach. The application of pelvic lymphadenectomy in patients with early endometrial cancer is useful because it has a diagnostic role and a therapeutic role, prevents metastasis. It could be concluded that: endometrial cancer surgery can be conducted using an open procedure with high effectiveness in terms of nodal excision and complication rate and increased operational and postoperative enforcement.

        Staging endometrial carcinoma to include pelvic lymphadenectomy in the recognition that lymph node status is one of the patients' most important prognostic factors. This led to widespread variations. Pelvic lymphadenectomy allows for accurate prognosis based on a pathological examination of the lymph node. It is an important marker of tumor aggressiveness Lymphadenectomy distinguishes patients with advanced disease and helps tailor adjuvant therapy for those with adverse risk factors. Thus, it can be concluded that: 1-Pelvic lymphadenectomy has a diagnostic role in the management of adjuvant therapy. Pelvic lymphadenectomy may have a therapeutic benefit, but more studies are needed to confirm this role.

        Research Article Pages: 1 - 7

        Neoadjuvant Chemotherapy Followed by Chemoradiation: Is it Tolerable and Efficient in Management of Locally Advanced Cervical Cancer?

        Heba Abdallah

        DOI: 10.37421/jcst.2020.12.641

        Background: Chemoradiation is the standard of care for management of locally advanced cervical cancer, but failure to control systemic disease occurs in one third of patients. Neoadjuvant chemotherapy (NACT) has been investigated in management of locally advanced cervical cancer in order to improve its prognosis. We assessed the tolerability and response rate of weekly NACT with paclitaxel and carboplatin before radical concurrent chemoradiation (CRT).
        Methods: Single arm phase II trial of 50 patients with locally advanced cervical cancer (stage IB2-IVA). Patients received weekly paclitaxel (80 mg/ m2 ) and carboplatin AUC2 for six cycles followed by CRT (weekly cisplatin 40 mg/m2 , 50.4 Gray over 28 fractions plus brachytherapy).
        Results: A total of 50 patients were recruited. Baseline characteristics were: median age at diagnosis 56 years, 92% squamous, 8% adenocarcinoma, FIGO stage IB2 ( 4%), II (28%), IIIA (28%), IIIB (12%), IVA (28%). Complete or partial response rate was 88.3% post NACT and 72.1% post CCRT. The median follow up was 12 months. Grade 3 toxicities were 14.8% during NACT and 13.8% during CCRT.
        Conclusion: Dose-dense weekly NACT with paclitaxel and carboplatin followed by CRT achieved a good response rate. It is feasible with acceptable toxicity of NACT and high compliance to radiotherapy.

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