Department of Medical Oncology, Pisan University Hospital, Pisa, Italy
 Case Report   
								
																Durable Complete Response to First Line Treatment with Avelumab in an Elderly, Multimorbid Patient with Advanced Merkel Cell Carcinoma: A Case Report 
																Author(s): Enrico Sammarco*, Amedeo Nuzzo, Simona Manacorda, Fiorella Manfredi, Chiara Mercinelli, Marco Ferrari, Giulia Massaro, Adele Bonato, Alessia Salfi, Debora Serafin, Luca Zatteri Luca, Galli Andrea Antonuzzo and Gianluca Masi             
								
																
						 Introduction: Metastatic Merkel Cell Carcinoma (MCC) is characterized by poor prognosis and poor response to cytotoxic chemotherapy. Immune Checkpoint Inhibitors (ICIs) were evaluated in several clinical trials, providing interesting results in terms of activity and efficacy, with a generally manageable safety profile. Limited data are available for use of ICIs in patients affected by multiple chronic diseases. We present the case of a patient with several comorbidities treated with Avelumab for advanced MCC, who developed a durable complete response.
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																DOI:
								10.37421/1948-5956.2022.14.S8.008															  
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