Journal of Cancer Clinical Trials

ISSN: 2577-0535

Open Access

Current Issue

Volume 6, Issue 7 (2021)

    Editorial Pages: 1 - 2

    Delayed Immunotherapy in Melanoma Carcinoma

    Mrinal Rocco

    Immunotherapies, including hostile to customized cell passing protein 1 (PD-1) antibodies (against PD-1) and hostile to cytotoxic Tlymphocyte-related protein 4 (CTLA4) antibodies (against CTLA4), have changed the therapy scene across numerous kinds of disease. Through restraint of PD-1 and CTLA4 designated spots, the antitumour insusceptible reaction can be expanded, however this can likewise have immune system impacts, named safe related antagonistic occasions (irAEs). While the range and the board of irAEs are to a great extent comparative whether prompted by against PD-1, hostile to CTLA4 or blend treatment, the recurrence and seriousness of irAEs vary. A higher occurrence and grade of irAE is seen with against CTLA4 regimens.1 Anti-PD-1 is by and large all around endured.

    Commentary Pages: 1 - 2

    Protein Kinase Signalling and Kinase Suppressor for Hepatocellular Carcinoma

    Adam Caroline

    Hepatocellular carcinoma (HCC) is the third driving reason for malignant growth related mortality worldwide and represents about 80% of all essential liver tumors. HCC is consequently a significant worldwide medical condition, and its occurrence proceeds to rise. The determination of HCC has worked on altogether in the course of recent years; be that as it may, under 30% of patients are determined to have HCC in the beginning phases, notwithstanding the accessibility of resection, liver transplantation, and neighborhood ablation. Systemic treatment is suggested as the standard treatment choice for cutting edge HCC; nonetheless, anticipation has been inadmissible in general. Normal danger factors for HCC incorporate hepatitis B infection (HBV) disease, hepatitis C infection (HCV) contamination, liquor utilization, aflatoxin B1 openness, and metabolic disorder.

    Commentary Pages: 1 - 1

    Myoepithelial Carcinoma with Combination Chemotherapy

    Thomas Kalhor

    Myoepithelial carcinoma is an uncommon threat that emerges essentially from the salivary organs, yet additionally from delicate tissue, skin, bone, and instinctive organs. It is viewed as rela-tively chemoresistant, with no standard therapy detailed inside the metastatic setting. EWS RNArestricting protein 1 (EWSR1) quality adjustments are available in roughly 82% of myoepithelial tumors emerging from delicate tissue, bone, and instinctive locations,7 just as in around 39% of clear cell myoep-ithelial carcinomas emerging from the salivary glands. POU class 5 homeobox 1 (POU5F1) is the combination accomplice of EWSR1 in roughly 28% of EWSR1 reworking positive myo-epithelial tumors emerging from delicate tissue, bone, and instinctive areas, with a predilec-tion toward a more dangerous phenotype. EWSR1 revamp is a pathognomonic component of Ewing sarcoma (but with vary ent combination accomplices: Fli-1 protooncogene, ETS record calculate [FLI1] around 90% of cases and ETS record consider ERG [ERG] around 10% cases).

    Commentary Pages: 1 - 1

    Pathologic and Radiologic Diagnosis of Hepatocellular Cholangiocarcinoma

    Chandrakanth Batra

    Hepatocellular-cholangiocarcinoma (cHCC-CCA) is an essential liver malignant growth (PLC) showing both hepatocytic and cholangiocytic separation, it supposedly represents around 1%-5% of all PLCs. Given the heterogeneous histopathologic nature of cHCC-CCAs, imaging or biopsy conclusion is testing, and the best indicative system for cHCC-CCAs in non-careful applicants isn't adequately distinct. Regardless of a few late examinations, the pathogenesis, histopathology, and hereditary qualities of this puzzling tumor have not been completely perceived. Considering the current agreement, the agreement phrasing of cHCC-CCA was distributed in 2018, and the WHO arrangement of cHCC-CCA was modified in 2019. Herein, we expected to extensively audit the refreshed data on the pathologic and radiologic analysis of cHCC-CCAs. cHCC-CCA is characterized as a PLC with the unequivocal presence of both hepatocytic and cholangiocytic separation inside a similar tumor, like WHO 2010 arrangement. cHCC-CCA is portrayed by complex morphological and immunophenotypical includes and can be analyzed paying little heed to the level of every segment if the parts are available unequivocally. Nonetheless, multi-central HCC or CCA, impact of HCC and CCA emerging independently, any type of hepatoblastoma or variations, pediatric momentary liver cell tumor or variations, and HCC or CCA with neuroendocrine segments ought not be named cHCC-CCAs. In the WHO 2010 arrangement, cHCC-CCAs were classified as "old style type" and three subtypes with immature microorganism highlights, including "run of the mill subtype," "transitional cell subtype," and "cholangiolocellular subtype"

    Editorial Pages: 1 - 1

    Microorganisms in the Treatment of Cancer

    Arnest T Wawk

    As Tumors of bosom, rectum or colon, lung, and prostate are answerable for half of all malignant growth cases in Europe; moreover, the initial three of them and furthermore the stomach disease are the most wellknown reasons for death from malignancy in the European Union. Disease is the subsequent significant reason for death in the USA. It is guessed that during the year 2017, more than 1.6 million cases will be enlisted, which implies that in excess of 4600 malignant growth cases will be accounted for consistently. It ought to be focused on that the insights might be belittled as numerous malignant growth sores create throughout the long term and are just analyzed at a high phase of the illness. There are numerous components that impact the advancement of malignancy.

    Volume 6, Issue 9 (2021)

      Editorial Pages: 1 - 1

      Circulating Blood from Patients with Metastatic Breast Cancer

      Alisa Kondo

      Metastasis is worked with by malignancy related fibroblasts (CAF) in the cancer microenvironment through instruments yet to be explained. In this review, we utilized a size-based microfilter innovation created by our gathering to analyze whether flowing CAF recognized by FAP and α-SMA co-articulation (cCAF) could be recognized in the fringe blood of patients with metastatic bosom malignancy. In a pilot investigation of patients with bosom malignancy, we distinguished the presence of cCAFs in 30/34 (88%) patients with metastatic sickness (MET bunch) and in 3/13 (23%) patients with restricted bosom malignancy (LOC bunch) with long haul infection free endurance. No cCAFs as characterized were distinguished in sound contributors. Further, both cCAF and flowing cancer cells (CTC) were altogether more prominent in the MET bunch contrasted and the LOC bunch

      Editorial Pages: 1 - 1

      Neuroendocrine in Human Prostate Cancer Cells

      Bernd Christmann

      Neuroendocrine cells are exceptionally particular neuron-like cells with curious secretory capacities, which are generally dispersed all through the human body including non-neuroendocrine organs like prostate. In typical prostatic parenchyma, neuroendocrine cells are essential for a diffuse framework that adds to the homeostasis of the encompassing epithelial populace. The neuroendocrine framework acts through its discharged items like calcitonin, parathyroid chemical related protein (PTHrP), chromogranins (CgA, CgB), neuron-explicit enolase (NSE), neurotensin, serotonin, bombesin, and somatostatin . These peptide chemicals and biogenic amines can either be delivered into the circulation system or act locally by paracrine or autocrine motioning in an androgen-autonomous way

      Editorial Pages: 1 - 1

      Urokinase Receptor Promotes Skin Tumor Formation Activation

      Tenley Pomeroy

      The urokinase-type plasminogen activator receptor (uPAR) plays a grounded part in malignant growth movement, however it has been minimal learned at before phases of disease inception. Here, we show that uPAR lack in the mouse drastically diminishes vulnerability to the old style twostage convention of incendiary skin carcinogenesis. uPAR hereditary lack diminished papilloma development and sped up keratinocyte separation, impacts intervened by Notch1 hyperactivation. Remarkably, Notch1 hindrance in uPAR-insufficient mice safeguarded their defenselessness to skin carcinogenesis. Clinically, we tracked down that human separated keratoacanthomas communicated low degrees of uPAR and significant degrees of enacted Notch1, with inverse impacts in multiplying cancers, affirming the pertinence of the perceptions in mice.

      Editorial Pages: 1 - 1

      Heightening Energetic Stress NonÔ??Small Cell Lung Cancers

      Ruty Toren

      Inactivation of the LKB1 cancer silencer is a regular occasion in non–little cell lung carcinoma (NSCLC) prompting the initiation of mTOR complex 1 (mTORC1) and affectability to the metabolic pressure inducer phenformin. In this review, we investigated the combinatorial utilization of phenformin with the mTOR synergist kinase inhibitor MLN0128 as a treatment procedure for NSCLC bearing comutations in the LKB1 and KRAS qualities. NSCLC is a hereditarily and neurotically heterogeneous sickness, leading to lung cancers of fluctuating histologies that incorporate adenocarcinomas and squamous cell carcinomas (SCC). We exhibit that phenformin in mix with MLN0128 actuated a huge restorative reaction in KRAS/LKB1–freak human cell lines and hereditarily designed mouse models of NSCLC that foster the two adenocarcinomas and SCCs.

      Commentary Pages: 1 - 3

      Early Use of Next Generation Sequencing Provided Alternative Treatment Options to 32.24% of Advanced Stage Cancer Patients (Avoiding or Delaying Chemotherapy)-Retrospective Study in Solid Tumors at Beverly Hills Cancer Center

      Nathan Gabayan, Ali Muhammad

      Our providers’ continuous efforts to obtain Next-Generation Sequencing for their cancer patients as early as possible followed by appropriately matched therapy has provided new therapeutic options to our patients. This retrospective study included 95 solid tumor patients who were genotyped with the FDA-approved Guardant360 CDx liquid biopsy that provides comprehensive genomic results from a blood draw in seven days X (https:// Our oncologists use it on regular basis for tumor mutation profiling, also known as comprehensive genomic profiling (CGP), across all solid cancers

      Volume 6, Issue 8 (2021)

        Editorial Pages: 1 - 1

        acute myeloid leukemia with or without venetoclax-based therapy

        Mrinal Roxana

        Tumor microenvironments can incorporate organisms that live in or close to the tumor. Microorganisms can adjust the microenvironment by creating factors that impact disease cells. For instance, certain strains of E. coli produce colibactin poison that is all the more generally found in the mucosa of people with colorectal disease than sound controls. Colibactin instigates cells in the microenvironment to create development factors which may advance tumor development. Another way that organisms can impact the microenvironment is through delivering bacterial biofilms which have been related with higher cell expansion rates and expanded danger of colorectal malignant growth. The tumor microenvironment in gastrointestinal tissue can be affected by the entirety of the microorganisms and supplements that are available. Subsequently, what and the amount we eat can downstreamly affect the nature of gastrointestinal tissues in manners that advance or cutoff malignant growth.

        Editorial Pages: 1 - 1

        human papillomavirusÔ??host genomic integration events in cancer

        Smily Rose

        The analytic model forecast result is parallel; HCC tests were relegated as one, while CRCLM and sound people were relegated as nothing. For model improvement, the example quality information included RNA fixation and their 260/280 and 260/230 absorbance proportions, cDNA fixation and their 260/280 and 260/230 absorbance proportions, and the explicitness of each miRNA softening bend. All highlights were normalized by the StandardScaler bundle in python. For every calculation, 30 models were first created, and their mean precision was taken for assessment. To additionally look at the presentation of the calculations, affectability, particularity, positive prescient esteem (PPV), negative prescient worth (NPV), region under bend (AUC), collector working trademark (ROC) bends were registered in python. All trials, investigation, and AI demonstrating for the solid, HCC.

        Editorial Pages: 1 - 1

        outcomes in patients with advanced and/or metastatic nonÔ??small cell lung cancer

        Alisa Yusuf

        Turn around reciprocal groupings or RNA restricting proteins (RBPs) are likewise needed for the arrangement of circRNAs. circRNAs additionally may go about as protein wipes, by restricting RNA-restricting proteins (RBPs) which can go about as activators or inhibitors of circRNAs development. Muscle dazzle protein (MBL) can emphatically and explicitly tie to the circRNAs which are produced from its own RNA. The RNA arrangement between the MBL dimers shapes a rope structure, which permits the receptor and the benefactor to be spatially near one another; in this way inciting RNA turn around joining, ruining direct grafting, and invigorating circMBL creation. RNA blending rivalry between or inside a solitary flanking intron may fundamentally affect grafting determination and result in the handling of numerous circRNAs records from a solitary quality by corresponding successions (rehashes or non-tedious arrangements) which might be gainful for exon cyclization. Exon circularization can likewise be intervened by integral arrangements in human introns

        Editorial Pages: 1 - 1

        COVID-19 and patients with cancer treatment

        Smily Wiliams

        The antagonistic human wellbeing impacts due to ionizing radiation are notable. Radon is the significant wellspring of foundation radiation among those that are of normal beginning. It contributes about 55% of the regular radiation portion to people. It is a dismal, unscented, and boring radioactive honorable gas that comes from the regular radioactive rot series of uranium. Radon can be discovered wherever in the environment and become appended to vaporizers noticeable all around.

        Editorial Pages: 1 - 1

        Chronic comorbid conditions among adult cancer

        Catherine Rose*

        The chi-square test was utilized for all out information. The ideal cutoff worth old enough as far as OS was dictated by X-tile programming (Yale University, New Haven, CT, USA). To handle the information helpfully, we isolated the patients into three gatherings as per age (79 years). Univariate and multivariate COX corresponding perils relapse investigations of the preparation partner were utilized to distinguish autonomous prognostic variables from which prescient models were built. Beneficiary working trademark (ROC) bends and the region under the bend (AUC) were utilized to assess the segregation of the nomogram. The alignment bend is a graphical showcase of adjustment exactness and is utilized to quantify the understanding of anticipated probabilities with genuine endurance results. To additionally evaluate the advantages and benefits of the prescient model, we utilized choice bend investigation (DCA). All assessment measures were directed and multiplied.

        Volume 6, Issue 5 (2021)

          Editorial Pages: 1 - 1

          Role of the Microbiome in Cancer

          Nguan Soon Tan

          The human gut is an assorted environment including growths, microscopic organisms, infections, and archaea, of which microbes from the phyla Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria are most predominant. Microorganisms can help keep up the intestinal obstruction which holds conceivably hurtful creatures back from arriving at the epithelium where they can cause ailment and injury. At present, organisms are accepted to add to malignancy hazard by changing DNA in human substantial cells subsequently modifying cell cycle controls, speeding up cell expansion, and upsetting typical projects for controlled cell passing that shield the body from atypical cells.Microbes have been connected to around 10–20% of human diseases.

          Editorial Pages: 1 - 1

          Hepatocellular Carcinoma & Liver Metastasis

          Matthew Hartke

          Hepatocellular carcinoma (HCC) is an exceptionally lethal malignancy with a loss of life more than 810,000 passings each year overall. Most HCC patients are recognized just in cutting edge stages with a grim forecast of short of what one-year generally speaking endurance. Symptomatic what's more, treatment delays are regularly connected to more terrible endurance results in HCC. Almost 20% of patients hang tight for over a quarter of a year from clinical show to determination, which is near the tumor volume multiplying season of HCC.

          Editorial Pages: 1 - 1

          Pancreatic Cancer in Circular RNAs

          Katsunori Baba

          Pancreatic malignancy (PaCa) is a forceful danger portrayed by solid attack. PaCa is likewise hard to fix and has a helpless anticipation, genuinely falling apart the patients' personal satisfaction. Because of the absence of successful biomarkers for the early analysis of this danger, patients regularly get treatment when it is past the point of no return and the endurance pace of patients determined to have PaCa following five years is < 6% . As of late, round RNA (circRNAs) is turning into a new examination area of interest in the field of RNAs

          Commentary Pages: 1 - 2

          Small Cell Lung Cancer Patients with Bone Metastasis

          Catherine Rose

          Cellular breakdown in the lungs is the main source of disease related demise around the world, and of all the subtypes, little cell cellular breakdown in the lungs (SCLC) represents roughly 15% of recently analyzed cellular breakdown in the lungs every year. SCLC is the most forceful sort among the cellular breakdown in the lungs subtypes and is regularly joined by metastasis at the hour of conclusion. The occurrence of far off metastases at the hour of starting finding of SCLC is higher than 60%, and perhaps the most widely recognized locales of metastasis is the bone.

          Commentary Pages: 1 - 1

          Health Hazard Overview of Radon Studies

          Smily Wiliams

          The antagonistic human wellbeing impacts due to ionizing radiation are notable. Radon is the significant wellspring of foundation radiation among those that are of normal beginning. It contributes about 55% of the regular radiation portion to people. It is a dismal, unscented, and boring radioactive honorable gas that comes from the regular radioactive rot series of uranium. Radon can be discovered wherever in the environment and become appended to vaporizers noticeable all around.

          Volume 7, Issue 1 (2022)

            Perspective Article Pages: 1 - 1

            Perspective on Advanced Cancer Research

            William Tandey*

            DOI: 10.37421/jcct.2022.7.143

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            Volume 7, Issue 2 (2022)

              Brief Report Pages: 1 - 1

              A Report on Cancer Therapy Care

              John Telenda*

              DOI: 10.37421/jcct.2022.7.149

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              Volume 7, Issue 3 (2022)

                Volume 7, Issue 4 (2022)

                  Volume 7, Issue 5 (2022)

                    Volume 8, Issue 3 (2023)

                      Mini Review Pages: 1 - 2

                      The Silent Threat: Hepatitis and its Link to Liver Cancer

                      Hernandez Felix*

                      DOI: 10.37421/2577-0535.2023.8.227

                      Hepatitis, a group of viral infections that target the liver, has long been recognized as a silent threat to global public health. This insidious disease affects millions of people worldwide, often going undetected until it progresses to severe stages. What many people don't realize is that hepatitis can have a direct and deadly link to liver cancer. Hepatitis is a viral infection that primarily targets the liver, the body's detoxifying and metabolic powerhouse. There are several forms of hepatitis, with hepatitis A, B, C, D and E being the most common. Each type is caused by different viruses and is transmitted through various means. While hepatitis A and E typically result in acute infections that resolve on their own, hepatitis B and C can lead to chronic infections that may persist for years, often causing extensive liver damage. Liver cancer, also known as hepatocellular carcinoma (HCC), is a malignancy that originates in the liver. It is a significant global health concern due to its high mortality rate and often latestage diagnosis.

                      Mini Review Pages: 1 - 2

                      The Critical Role of Clinical Trial Management in Advancing Cancer Research

                      Larsson Anette*

                      DOI: 10.37421/2577-0535.2023.8.226

                      Cancer is a complex and multifaceted disease that affects millions of lives worldwide. While the diagnosis of cancer can be devastating, the progress made in cancer research and treatment offers hope to patients and their families. Clinical trials, often referred to as the gold standard for evaluating new cancer therapies, play a pivotal role in this ongoing battle against the disease. Behind every successful clinical trial lies an essential component: clinical trial management. Clinical trials are carefully designed, controlled experiments that assess the safety and efficacy of new treatments, drugs, or interventions. These trials involve a diverse range of patients, each with a unique set of circumstances and medical history. Proper management is crucial to ensure the success and integrity of these trials.

                      Mini Review Pages: 1 - 2

                      Bladder Cancer Research: Latest Breakthroughs and On-going Studies

                      Baraud Kenji*

                      DOI: 10.37421/2577-0535.2023.8.218

                      Bladder cancer is a formidable adversary, affecting millions of people worldwide and causing substantial morbidity and mortality. However, the field of bladder cancer research has made remarkable progress in recent years. Before delving into recent advancements, it's crucial to understand the basics of bladder cancer. This form of cancer begins in the bladder, the organ responsible for storing urine. Bladder cancer typically starts in the urothelial cells that line the interior of the bladder, but it can also develop in other cell types. Risk factors for bladder cancer include smoking, exposure to certain chemicals, chronic bladder inflammation and genetic predisposition. The immune system is the body's natural defense against foreign invaders, including cancer cells. However, cancer can sometimes evade the immune system's surveillance, allowing it to grow and spread. Bladder cancer, like many other cancer types, can create an immunosuppressive microenvironment, making it challenging for the immune system to recognize and combat the disease.

                      Mini Review Pages: 1 - 2

                      Collaboration and Multicentre Trials Managing Complexity in Cancer Research

                      Watanabe Fabienne*

                      DOI: 10.37421/2577-0535.2023.8.219

                      Cancer research is a complex and multifaceted field, requiring the collaboration of diverse experts and resources to make meaningful advancements. In the quest to understand, diagnose and treat cancer, multicenter trials have emerged as a crucial tool for managing complexity. These trials involve multiple institutions, researchers and patients working together to investigate the intricacies of cancer. This article delves into the significance of collaboration and the management of complexity in cancer research through multicenter trials. Cancer is not a single disease but rather a collection of diseases characterized by abnormal cell growth. It can manifest in various forms, with diverse causes, risk factors and outcomes. This inherent complexity necessitates a multifaceted approach to unravel its mysteries and develop effective treatments. Cancer research involves understanding the molecular underpinnings, identifying potential biomarkers, developing diagnostic tools and conducting clinical trials to evaluate therapeutic interventions.

                      Short Communication Pages: 1 - 2

                      Ensuring Data Quality and Integrity in Cancer Clinical Trials

                      Ezzati Satter*

                      DOI: 10.37421/2577-0535.2023.8.220

                      Cancer clinical trials play a pivotal role in advancing our understanding of cancer and developing new treatments. These trials are meticulously designed to evaluate the safety and efficacy of novel therapies. One critical aspect that underpins the success of these trials is the quality and integrity of the data collected. Ensuring data quality and integrity in clinical trial is of paramount importance to draw valid and reliable conclusions, make informed decisions and ultimately improve patient outcomes. Cancer research has made significant strides in recent years, leading to a better understanding of the disease and the development of innovative treatments. Data quality and integrity are fundamental aspects of this progress. Reliable data collection, management and analysis are essential for drawing accurate conclusions, making informed decisions and advancing cancer research. In this article, we will explore the critical role of data quality and integrity in cancer research and the strategies employed to ensure their maintenance.

                      Short Communication Pages: 1 - 2

                      Environmental Factors and Lung Cancer beyond Smoking

                      Anthony Philip*

                      DOI: 10.37421/2577-0535.2023.8.221

                      Lung cancer is one of the most prevalent and deadly cancers globally, accounting for a significant portion of cancer-related deaths each year. While smoking remains the primary risk factor for lung cancer, it is essential to recognize that several environmental factors play a crucial role in the development and progression of this disease. Understanding these factors is vital not only for prevention but also for addressing the growing incidence of lung cancer in non-smokers. Lung cancer is a formidable and often fatal disease that has long been associated with smoking. While cigarette smoking remains the leading cause of lung cancer, it's crucial to understand that this deadly disease can also affect non-smokers due to a range of factors, including genetics, environmental exposures and occupational hazards.

                      Commentary Pages: 1 - 2

                      Genetic Predisposition: BRCA Gene Mutations and Ovarian Cancer

                      Mudge Elizabeth*

                      DOI: 10.37421/2577-0535.2023.8.222

                      Genetics plays a pivotal role in our susceptibility to various diseases and one of the most well-known connections between genetic mutations and cancer risk is the link between BRCA gene mutations and ovarian cancer. The discovery of these mutations has transformed our understanding of hereditary ovarian cancer and opened the door to proactive risk management and early detection strategies. BRCA1 and BRCA2 are tumor suppressor genes that are instrumental in DNA repair. Mutations in these genes increase the risk of developing breast and ovarian cancers. The BRCA1 gene is located on chromosome 17, while BRCA2 is situated on chromosome 13. These genes encode proteins that help repair damaged DNA, preventing the accumulation of genetic errors that can lead to cancer.

                      Commentary Pages: 1 - 2

                      Immunotherapy and Targeted Therapies in Breast Cancer Treatment

                      Sawicki Tomasz*

                      DOI: 10.37421/2577-0535.2023.8.223

                      Breast cancer is a complex and heterogeneous disease that affects millions of women worldwide. While traditional treatment modalities such as surgery, chemotherapy and radiation therapy have been cornerstones in the fight against breast cancer, the landscape of breast cancer treatment is evolving rapidly. Two promising avenues in this evolution are immunotherapy and targeted therapies. These innovative approaches have shown great promise in improving treatment outcomes, reducing side effects and offering new hope to breast cancer patients. Immunotherapy is a groundbreaking approach that harnesses the body's own immune system to target and destroy cancer cells. In breast cancer, immunotherapy has gained significant attention, particularly in cases that are resistant to conventional treatments. The future of immunotherapy in breast cancer looks promising. Ongoing research aims to refine patient selection, develop novel combination therapies and optimize treatment regimens. Advancements in understanding the tumor microenvironment, the role of the immune system and the genetics of breast cancer will continue to drive progress in this field.

                      Perspective Pages: 1 - 2

                      Patient Reported Outcomes in Cancer Clinical Trials: Measuring the Human Element

                      Dudkaitė Gintautas*

                      DOI: 10.37421/2577-0535.2023.8.224

                      Cancer clinical trials have long been the cornerstone of medical research, providing critical insights into the effectiveness of novel treatments and therapies. Traditionally, clinical endpoints in these trials have relied heavily on objective measures, such as tumor size reduction or progressionfree survival. While these measures are undeniably valuable, they often fall short in capturing the full impact of cancer and its treatment on patients' lives. This is where Patient Reported Outcomes (PROs) come into play, offering a more comprehensive and patient-centered approach to understanding the human element of cancer clinical trials. PROs encompass a wide range of self-reported data, including patient perspectives on symptoms, functioning, quality of life and treatment side effects. By collecting and analyzing PROs in clinical trials, researchers can gain a deeper understanding of how patients experience cancer and its treatments beyond mere clinical metrics. This patient-centric data is invaluable in assessing treatment efficacy, making informed decisions and improving the overall cancer care journey.

                      Perspective Pages: 1 - 2

                      Rare Cancers and Clinical Trials Progress in the Face of Rarity

                      Senapati Dulal*

                      DOI: 10.37421/2577-0535.2023.8.225

                      Cancer is a formidable adversary, affecting millions of lives worldwide. While common cancers like breast, lung and prostate cancers dominate the public health landscape, there exists a group of malignancies that are far less prevalent but equally devastating - rare cancers. These rare cancers pose unique challenges for both patients and healthcare providers. However, there is hope on the horizon, as clinical trials are making significant progress in the face of rarity, offering new possibilities for those affected by these less common but often aggressive diseases. Rare cancers, also known as orphan cancers, are those with a lower incidence compared to more prevalent malignancies. Although no universal consensus defines the threshold for rarity, the American Cancer Society suggests that cancers with an incidence of fewer than six cases per 100,000 people per year fall into this category. Some examples of rare cancers include cholangiocarcinoma (bile duct cancer), mesothelioma and sarcomas.

                      Volume 8, Issue 1 (2023)

                        Mini Review Pages: 1 - 3

                        Advancements and Challenges in Cancer Clinical Trials: An Overview and Review of Literature

                        Dean Sittig*

                        DOI: 10.37421/2577-0535.2023.8.202

                        Cancer is a prevalent disease that affects millions of people worldwide. Clinical trials are crucial in developing new cancer treatments and improving the efficacy of existing ones. This paper provides an overview of cancer clinical trials, including their significance, types, and the process involved in conducting them. Additionally, the paper reviews literature on the latest advancements in cancer clinical trials and their impact on cancer treatment outcomes. The discussion section highlights the challenges faced in cancer clinical trials and suggests future directions for cancer research. The conclusion emphasizes the importance of clinical trials in advancing cancer treatment and improving patient outcomes. Introduction: Cancer is a complex and challenging disease that affects individuals across all ages and demographics. According to the World Health Organization (WHO), cancer is one of the leading causes of death worldwide, accounting for approximately 10 million deaths. Despite significant progress in cancer treatment, there is still a need for more effective treatments to improve patient outcomes. Clinical trials are an essential tool in the fight against cancer, as they provide critical information on the safety and efficacy of new cancer treatments.

                        Mini Review Pages: 1 - 2

                        Cannabis-derived Product's Benefits, Drawbacks and Risks as a Cancer Treatment

                        Dean Sittig*

                        DOI: 10.37421/2577-0535.2023.8.203

                        Patients especially are interested in the use of cannabis products in oncology. The added value of curative or palliative cancer care as well as the potential risks associated with it is not sufficiently demonstrated, so they remain a topic of debate despite the abundance of available research data. By reviewing the most recent research, our goal is to make a recommendation regarding the place of cannabis products in clinical oncology. The characteristics, quality, and pharmacology of various cannabis products are discussed. For quality that can be trusted and replicated, standardization is essential. In comparison to inhalation and drinking tea the mucosal/sublingual route of administration is preferred. Cannabinoids might repress efflux carriers and medication utilizing catalysts, conceivably prompting pharmacokinetic collaborations with anticancer medications being substrates for these proteins. This might make the cytostatic effect stronger or make drug-related side effects worse. On the other hand, it might make dose reduction possible. With medications used to treat anorexia, pain, nausea, and vomiting, similar interactions are likely. Cannabis products may improve the quality of life of cancer patients (although this has not been conclusively demonstrated) and are typically well tolerated. The mix with immunotherapy appears to be bothersome in view of the immunosuppressive activity of cannabinoids. To scientifically support (refrain from) using cannabis products in cancer patients, additional clinical research is required.

                        Advancements in Cancer (2021)

                          Editorial Pages: 1 - 2

                          Lung Cancer Immunotherapy

                          Bruce W Robinson*

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                          Commentary Pages: 1 - 2

                          Multiple Primary Lung Cancer

                          Bruce F Sabath*

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                          Volume 6, Issue 2 (2021)

                            Commentary Pages: 1 - 2

                            Chemotherapy for Acute Lymphocytic Leukemia (ALL)

                            Baron Ronson

                            Chemotherapy (chemo) is the utilization of medications to treat disease. Chemo drugs venture out through the circulatory system to arrive at disease cells everywhere on the body. This makes chemo helpful for diseases, for example, leukemia that has spread all through the body. Chemo is the principle treatment for pretty much all individuals with intense lymphocytic leukemia (ALL). In view of its possible results, chemo probably won't be suggested for patients in chronic weakness, yet progressed age without anyone else isn't an obstruction to getting chemo.

                            Editorial Pages: 1 - 2

                            Cancer Radiation Therapy

                            Rajashekaram Baskar

                            Radiation treatment (likewise called radiotherapy) is a malignancy therapy that utilizes high dosages of radiation to slaughter disease cells and psychologist tumors. At low dosages, radiation is utilized in x-beams to see inside your body, similarly as with x-beams of your teeth or broken bones. At high dosages, radiation treatment slaughters disease cells or eases back their development by harming their DNA. Malignancy cells whose DNA is harmed unrecoverable quit separating or passes on. At the point when the harmed cells pass on, they are separated and taken out by the body. Radiation treatment doesn't execute disease cells immediately. It requires days or long stretches of therapy before DNA is harmed enough for malignant growth cells to kick the bucket.

                            Editorial Pages: 1 - 2

                            Leukemia Cancer Disorders and Treatments

                            Dearden Richard

                            Leukemia is a danger of cell section in the blood and bone marrow. It is essentially related to the platelets, for instance, White platelets which joins blood issue in the platelets and the appearances are revealed in the protected game plan of the person which cripples the safe course of action of the individual achieving the skin issues, for instance, rashes, skin issue. Leukemia has a treatment, for instance, chemotherapy which helps in lessening the abnormalities anyway it can't fix it completely. Journal Article is a portion of the time called a Scientific Article, a Peer-Reviewed Article, or a Scholarly Research Article. Together, journal articles in a particular field are much of the time insinuated as The Literature. Journal articles are often Primary Research Articles. Regardless, they can similarly be Review Articles.

                            Short Communication Pages: 1 - 3

                            Brain Tumor Radiation Therapies

                            Peter A Recci

                            A brain tumor is a gathering of unusual cells that fills in or around the mind. Tumors can straightforwardly annihilate solid synapses. They can likewise in a roundabout way harm solid cells by swarming different pieces of the brain and causing irritation, mind expanding and pressure inside the skull. Brain tumors are either harmful or kindhearted. A harmful tumor, additionally called mind malignant growth, develops quickly and frequently attacks or groups sound territories of the brain. Amiable brain tumors don't contain malignancy cells and are typically sluggish developing. Brain tumors fall into two unique classes: essential or metastatic. Essential brain tumors start inside the mind.

                            Short Communication Pages: 1 - 2

                            Preventions and Treatments of Lymphoma Disease

                            Richard F. Yusuf

                            About portion of the blood malignant growths that happen every year are lymphomas, or diseases of the lymphatic framework. This framework - made out of lymph hubs in your neck, armpits, crotch, chest, and midregion - eliminates overabundance liquids from your body and delivers insusceptible cells. Unusual lymphocytes, a sort of white platelet that battles disease, become lymphoma cells, which increase and gather in your lymph hubs. Over the long run, these destructive cells impede your resistant framework.

                            Volume 6, Issue 3 (2021)

                              Research Article Pages: 1 - 7

                              A Risk Score to Evaluate the Risk of Lung Cancer in People with HIV

                              Vincent J. Amoruccio, Dinesh P. Mital and Shankar Srinivasan

                              The advent of antiretroviral therapy (ART) changed the prognosis of HIV. People with HIV (PWH) live longer lives but are susceptible to the same age-related disease as people without HIV. Cancer is a leading cause of death for PWH, and lung cancer is the leading cause of cancer-related death. Smoking and increased age are the primary causes of lung cancer in the general population; however, risk factors specific to HIV, such as immunocompetence and respiratory disease, present additional lung cancer risk in PWH. Existing guidance from the National Lung Cancer Screening Trial (NLST) excludes PWH, does not consider HIVspecific risk factors, and misses significant amounts of lung cancer cases in PWH when it is applied. This deficiency has led to increased incidence and mortality from lung cancer and at younger ages and more advanced stages.

                              Editorial Pages: 1 - 1

                              Lung Carcinoma Disorders

                              Thomas Kalhor *

                              Lung carcinoma is the main source of disease related passing around the world. About 85% of cases are identified with cigarette smoking. Manifestations can incorporate hack, chest distress or agony, weight reduction, and, less usually, hemoptysis; be that as it may, numerous patients present with metastatic illness with or with no clinical indications. The conclusion is regularly made by chest xbeam or CT and affirmed by biopsy. Contingent upon the phase of the sickness, therapy incorporates a medical procedure, chemotherapy, radiation treatment, or a blend. For as long as a very long while, the anticipation for a cellular breakdown in the lungs patient was poor, with just 15% of patients enduring > a long time from the hour of analysis. For patients with stage IV (metastatic) sickness, the 5-year generally speaking endurance rate was < 1%. Nonetheless, results have improved on account of the ID of specific changes that can be focused for treatment and current 5-year endurance rates are 19% (23% for ladies and 16% for men). The manifestations of cellular breakdown in the lungs rely upon its sort, its area, and the manner in which it spreads inside the lungs, to zones close to the lungs, or somewhere else in the body

                              Editorial Pages: 1 - 1

                              Skin Cancer Therapies

                              Adam Caroline *

                              Skin malignancy — the strange development of skin cells — frequently creates on skin presented to the sun. In any case, this regular type of malignancy can likewise happen on spaces of your skin not customarily presented to daylight. There are three significant sorts of skin malignancy — basal cell carcinoma, squamous cell carcinoma and melanoma. You can decrease your danger of skin malignancy by restricting or keeping away from openness to bright (UV) radiation. Checking your skin for dubious changes can help recognize skin disease at its most punctual stages. Early identification of skin disease gives you the best possibility for fruitful skin malignant growth treatment. Skin malignancy grows basically on spaces of sununcovered skin, including the scalp, face, lips, ears, neck, chest, arms and hands, and on the legs in ladies. Yet, it can likewise shape on regions that once in a while come around — your palms, underneath your fingernails or toenails, and your genital territory. Skin malignant growth influences individuals of all skin tones, incorporating those with hazier appearances. At the point when melanoma happens in individuals with brown complexion tones, it's bound to happen in territories not regularly presented to the sun, like the palms of the hands and bottoms of the feet

                              Short Communication Pages: 1 - 1

                              Preventions and Therapies of Ovarian Cancer

                              Christina Titou *

                              In our arrangement, a background marked by harm was related with a raised danger of ischemic cardiovascular occasions and pos toperative profound vein apoplexy, while dynamic threat was related with expanded respiratory and renal inconveniences, hematoma/seroma development and early postoperative mortality. The two gatherings introduced expanded paces of by and large in-emergency clinic difficulties. Patients with bone metastasis to the hip exhibited expanded DVT and 90-day death rates. Malignancy patients have expanded dreariness and mortality after TJA and ought to go through far reaching clinical enhancement and adjusted thromboprophylaxis. As malignancy therapies keep on improving the general endurance rates, more patients with a background marked by disease will introduce for anatomic all out shoulder arthroplasty (TSA).

                              Short Communication Pages: 1 - 2

                              Advanced Cancer Preventions and Treatments

                              Mrinal Takefumi *

                              Regardless of our colossal and progress in medication, malignancy stays a top medical problem around the world. As indicated by late measurements, in excess of 8,000,000 individuals yearly capitulate to the illness in the world. Unmistakably we should work a lot harder to dispose of this sickness in the following a very long while. We have an expectation, in any case, that can urge us to do as such and push ahead: disease immunotherapy[1]. Fundamental immunotherapy for the therapy of disease has been examined for a long time and has attempted to turn into a central participant around there. Before new immunotherapy like safe designated spot inhibitors opened up in human investigations, the utilization of immunotherapy for cutting edge threat was extremely restricted. In spite of the fact that cytokine treatments, for example, IL-2 were accessible in center, their signs were restricted to melanoma and renal cell carcinoma. Indistinct endurance benefit in both infection settings and helpless bearableness made parental figures reluctant to recommend these specialists

                              Volume 6, Issue 4 (2021)

                                Commentary Pages: 1 - 1

                                Esophageal Cancer Radiochemotherapy

                                Chandrakanth Batra

                                Esophageal malignancy is one of the ten most incessant tumors around the world. There are two significant histologies: squamous cell carcinomas, which show up more regularly in the upper piece of the throat, and adenocarcinomas, which are prevalently found in the distal part and at the gastroesophageal intersection. Most patients experience the ill effects of privately progressed tumors, for which the anticipation is as yet poor with a 5-year endurance pace of 15–25%. Treatment depends on histology, tumor stage, area of the tumor, execution status, age, and comorbidities and it comprises of a medical procedure, chemotherapy, or radiotherapy or a mix of these.

                                Editorial Pages: 1 - 1

                                Chemotherapy-induced neutropenia and treatment

                                Chandrakanth Batra*

                                Platinum-based mix chemotherapy addresses the authentic first-line therapy in quite a while with cutting edge non-little cell cellular breakdown in the lungs (NSCLC), without targetable transformations, and great execution status (PS). During the '90s, this procedure turned into the norm of care because of a little however huge endurance advantage in grown-up patients. In any event, thinking about the new advances in treatment with focused specialists and resistant designated spot inhibitors, most patients are still possibility to get platinum-based chemotherapy. Chemotherapy-actuated neutropenia (CIN) is perhaps the most widely recognized unfavorable occasions revealed in malignant growth patients

                                Editorial Pages: 1 - 1

                                Chemo-resistant Leukemia Cells

                                Thomas Kalhor

                                Leukemia, positioning the primary spot in youthful individuals' harmful infections, is the dangerous tumor of hematopoietic framework. As of now, chemotherapy is still a significant treatment strategy for leukemia. However with the utilization of chemotherapy drugs, leukemia cells step by step create opposition coming about in chemotherapy disappointment. The acquired (regular) or procured drug opposition, particularly multidrug opposition (MDR) is viewed as the significant reason for chemotherapy disappointment. In spite of unmistakable components, MDR is generally the helpful impact of a mix of MDR systems like obstructing apoptosis and expanding drug efflux. Among drug efflux carriers, the most broadly examined is adenosine triphosphate-restricting tape (ABC) carriers

                                Editorial Pages: 1 - 1

                                A Cohort Study in the prostate Cancer and Lung Cancer

                                Adam Caroline

                                There is a developing group of proof that ibuprofen, a cyclooxygenase 1/2 inhibitor, may lessen the danger of kicking the bucket of cancer,although supposedly the instrument of activity and ideal planning of openness remain unclear.1,2Inbreast malignant growth, a few observational investigations have inspected relationship between anti-inflamatory medicine use and illness repeat ordeath.3-11Some of these examinations have announced measurably critical decreases in bosom disease mortality,3,5,10althoughthey didn't recognize ladies who started antiinflamatory medicine use in the prediagnostic versus postdiagnostic setting, andit is muddled what impact the circumstance of ibuprofen openness had on their outcomes. L

                                Editorial Pages: 1 - 1

                                Establishing Essentials Professional Development

                                Adam Caroline

                                Chemoprevention, and hazard decreasing gynecologic and colorectal medical procedures. Since ECs/OCs are regularly the sentinel malignancies in ladies with LS at a middle age at analysis of 47 years,4-6 the diagnosister of LS can open ways to viable colonoscopic watch spear, which prompts a 60% decrease in the rate of CRC and up to a 70% decrease in CRC-related human ity.7 Cascade testing of in danger family members will likewise recognize youthful unaffected people who might profit the most from an early determination of LS.Because of the significance of early LS ID, the National Comprehensive Cancer Network recom-retouches tumo

                                Volume 6, Issue 6 (2021)

                                  Editorial Pages: 1 - 1

                                  Establishing Professional in Essential Development

                                  Arsol Gourav

                                  Colorectal malignancy (CRC) is the third driving reason for disease related demise in the United States, with an expected 135 430 new cases and 50 260 malignancy related passings yearly. Albeit the occurrence and infection explicit mortality has bit by bit declined in the course of recent many years, late investigations depict an upsetting pattern of an expanded frequency in more youthful (<50 years) people. Most of patients determined to have metastatic colorectal malignant growth (mCRC) have serious sickness, except for those with oligometastatic illness, for which fruitful careful or ablative intercessions and foundational treatment has yielded 5-year and 10-year endurance paces of around 40% and 20%, individually

                                  Commentary Pages: 1 - 1

                                  Long Noncoding RNA MALAT1 Interacts Modulate Osteosarcoma

                                  Alisa Yusuf

                                  Osteosarcoma (OS) is a typical essential bone tumor with inclination in kids and teenagers, the occurrence of which has been positioned as the most elevated of all essential dangerous bone tumor types. Operating system is described by serious level of danger and early metastasis. Numerous patients with OS as of now have progressed illness with far off metastases at the hour of beginning show, and in this manner it presents incredible difficulties to clinical specialists. Operating system has a troubling guess after metastasis has happened albeit the 5-year endurance of treated OS patients has altogether expanded in the previous many years. Late forward leaps in the utilization of designated treatments in the administration of harmful tumors, like leukemia and cellular breakdown in the lungs, bring helpful motivation for OS treatment.

                                  Editorial Pages: 1 - 1

                                  Genome-Targeted Oncology Drugs

                                  Farhad Sahar

                                  Precision oncology depends upon genomic sequencing of a patient's tumor to decide ideal treatment.1 Precision treatments ordinarily target hereditary variations inside malignant growth, and this methodology has far and wide excitement driven by high reaction rates. Frequently, genomically-designated drugs acquire Food and Drug Administration (FDA) endorsement in single-arm preliminaries that do not have a comparator group.2 As such, reaction rates, which measure the level of patients who have tumor shrinkage past the RECIST 1.1 cut-off of 30%, are regularly utilized as an examination endpoint.3. Earlier investigations have assessed the level of US malignancy patients with cutting edge or metastatic disease who are qualified for and react to this class of prescriptions. In particular, genome-designated treatment was found to apply to 8.3% of US disease patients starting at 2018, and 4.9% may encounter a fractional or complete response.

                                  Commentary Pages: 1 - 1

                                  Relationship between Mycoplasmas and Cancer

                                  Caroline Thomas

                                  Malignancy is a sickness introducing an weight to humankind. As per most recent insights of the International Agency for Research on Cancer partnered to the World Health Organization, scarcely 18 million new malignancy cases were universally recorded in 2018, of which roughly 10 million have prompted demise. Many causes and hazard factors have been highlighted advance carcinogenesis foundation and improvement. Among these elements, some irresistible specialists have been suspected. Truth be told, as per the American Cancer Society, up to 20% of malignant growths worldwide have been identified with irresistible specialists. The causal connection between various kinds of disease and numerous oncoviruses, for example, papillomavirus, hepatitis B infection, and Epstein-Barr infection and microorganisms, for example, Streptococcus bovis, Salmonella typhi, Chlamydia pneumoniae, Bartonella, and Helicobacter pylori has recently been all around recorded

                                  Editorial Pages: 1 - 1

                                  Metastatic Castration-Resistant Prostate Cancer Immunotherapy

                                  Richard Caroline

                                  Androgen hardship treatment (ADT) is the pillar of therapy of cutting edge prostate cancer.1 Disease movement notwithstanding mutilate testosterone levels characterizes metastatic emasculation safe prostate malignancy (mCRPC) and messengers huge grimness and mortality. Middle endurance of mCRPC patients getting first-line androgen-receptor pathway inhibitors (ARPI, for example, abiraterone or enzalutamide, moved toward 3 years in enormous stage III trials.2,3 However, a subset of patients have unfavorable clinical highlights forecasting helpless results. These markers incorporate instinctive metastases, fast movement on ADT, execution status, and high blood centralizations of lactate dehydrogenase (LDH) and basic phosphatase (ALP)

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