Medicinal Chemistry

ISSN: 2161-0444

Open Access

Zahid Khan

Department of Chemistry, Women University, Swabi, Pakistan

  • Review   
    Schiff Bases and Their Transition Metal Complexes: A Review on Biological Facets
    Author(s): Zahid Khan*

    Schiff bases forms an important class of organic compounds the azomethine moiety present in these compounds renders them to exhibit a range of biological activities e.g. antimicrobial, antifungal antioxidant, α and β glucosidase and urease inhibition to name a few. The azomethine moiety is rich in electron density which is readily acceptable by electropositive transition metals that potentially opens up the possibility of a diverse array of metal-based candidate drug molecules. A huge number of such metal complexes are reported in the literature, this review presents a review of the literature examples and discussing various results primarily based on the role of azomethine involvement in chelation and the effect of other substitution in the close proximity with the azomethine group and their involvement in the complexation, furthermore the mechanism of biological action an.. Read More»

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