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Journal of Bioprocessing & Biotechniques

ISSN: 2155-9821

Open Access

Sofia A Pezoa

Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA

Publications
  • Review Article   
    Recent Advances of Chemical Definition of Cell Culture Media and Excipients for Virus and Viral Vector Manufacturing: A Review
    Author(s): Randall Alfano*, Atherly Pennybaker and Sofia A Pezoa

    A vital step in the manufacturing of vaccines and viral vector-based cell and gene therapies is virus production. Historically, virus production relies heavily on undefined and highly variable raw material for cell-based platforms to be successful. Yet due to supply chain constraints, poor reproducibility, and safety concerns attributed to potential adventitious agents present in serum and serum-derived proteins, regulatory agencies have encouraged replacement of these components. Recombinant serum proteins, specifically albumin and transferrin, can successfully replace serum-derived proteins in the expansion of VERO cells and subsequent production of multiple virus types. Furthermore, recent successes have demonstrated that recombinant human serum albumin can serve as an effective excipient in final formulations for the stabilization of virus in vaccines. Collective.. Read More»
    DOI: 10.37421/2155-9821.2021.11.482

    Abstract HTML PDF

Google Scholar citation report
Citations: 3351

Journal of Bioprocessing & Biotechniques received 3351 citations as per Google Scholar report

Journal of Bioprocessing & Biotechniques peer review process verified at publons

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