Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy
Short Communication
Estimating Human Skeletal Muscle Oxidative and Oxygen Diffusion Capacities Using Near-Infrared Spectroscopy
Author(s): Simone Pilotto*
During exercise, the culmination of the O2 cascade is contingent upon the interaction between microvascular to intramyocyte differences and
muscle O2 diffusion capacity. Presently, there is a lack of non-invasive techniques for determining in human subjects. Utilizing near-infrared spectroscopy
(NIRS) and intermittent arterial occlusions to measure the recovery rate constant (k) of muscle oxygen uptake (m), we have established
its correlation with in vivo muscle oxidative capacity. We postulated that k would be constrained by under conditions of low muscle oxygenation
(kLOW). We proposed two hypotheses: (i) k in optimally oxygenated muscle (kHIGH) is linked to the maximum O2 flux within fiber bundles; and (ii)
the difference (Δk) between kHIGH and kLOW is associated with capillary density (CD). In a study involving 12 particip.. Read More»
DOI:
10.37421/2684-494X.2023.8.69
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