Medicinal Chemistry

ISSN: 2161-0444

Open Access

Riffat Latif

Department of Pharmacy, Riphah International University, Lahore, Pakistan

  • Research Article   
    Fabrication and Characterization of Thiolated Chitosan Microneedle Patch of Azathioprine for Transdermal Drug Delivery
    Author(s): Fazal Ur Rehman*, Riffat Latif, Muhammad Tahir and Yasmeen Rasheed

    Micro needle patches are the novel dosage form in transdermal drug delivery systems with improved penetration to skin. In this study we fabricated micro needle patches containing azathioprine an immunosuppressant drug by using polymer thiolated chitosan that in turn was developed by adding thiol group to chitosan. These micro needle patches were further evaluated for their mechanical, physical and chemical parameters. The optimized micro needle patch having 225 needles with 665 μm length, 90 μm width showed good penetration i.e 84% and better percent elongation. In-vitro and ex-vivo penetration studies on rat skin using Franz diffusion cell showed sustained release of (85%) azathioprine in its comparative study with azathioprine ointment. HPLC analysis also showed 91.7% release of drug from optimized formulation of micro needle patch. Finally the recen.. Read More»
    DOI: DOI: 10.37421/2161-0444.22.12.631

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