Journal of Surgical Pathology and Diagnosis

ISSN: 2684-4575

Open Access

Rajiv Kumar

Department of Chemistry, Aditi Mahavidyalaya University of Delhi, NIET-National Institute of Medical Science, Delhi, India

  • Short Communication   
    Wound Pathophysiology: Insights of Ca2+ Signalling and Cellular Senescence Mechanisms in Healing and Regeneration
    Author(s): Rajiv Kumar*

    Cellular senescence and calcium signalling are interrelated phenomena of cellular events. As, cellular senescence is associated with stress, alongside it, intracellular calcium signalling has a concern with cellular senescence. Henceforth, both events participate in wound regeneration and governed few of its phases (re-epithelialization, tissue remodelling, inflammation and granulation). Despite it, mitochondrial Ca2+ uptake influences the phenomena of fibroblast and myofibroblast differentiation. Quantitative imaging and computational modelling expose hidden features of calcium signalling route. A proper investigation of the role of calcium in specific senescence-associated routes and physiopathological conditions will expose forefront of calcium signalling and its association with cellular senescence... Read More»

    Abstract PDF

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