Journal of Surgical Pathology and Diagnosis

ISSN: 2684-4575

Open Access

Wound Pathophysiology: Insights of Ca2+ Signalling and Cellular Senescence Mechanisms in Healing and Regeneration


Rajiv Kumar*

Cellular senescence and calcium signalling are interrelated phenomena of cellular events. As, cellular senescence is associated with stress, alongside it, intracellular calcium signalling has a concern with cellular senescence. Henceforth, both events participate in wound regeneration and governed few of its phases (re-epithelialization, tissue remodelling, inflammation and granulation). Despite it, mitochondrial Ca2+ uptake influences the phenomena of fibroblast and myofibroblast differentiation. Quantitative imaging and computational modelling expose hidden features of calcium signalling route. A proper investigation of the role of calcium in specific senescence-associated routes and physiopathological conditions will expose forefront of calcium signalling and its association with cellular senescence.


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