Journal of Surgical Pathology and Diagnosis

ISSN: 2684-4575

Open Access

Articles in press and Articles in process

    Case Report Pages: 1 - 3

    Behcet?s Disease Mimicking Crohn Disease: A Pathological Approach to a Case

    Jingjing Hu*, Andreas Ciscato and Mojgon Hosseini

    DOI: DOI: 10.37421/ 2684-4575.2022.4.3.123

    Bechet’s Disease (BD) is a rare entity. It’s a multi-systemic inflammatory disease of unknown etiology characterized by recurrent ulcers and vasculitis, mainly including oral cavity, eyes, gastrointestinal tract and joints. Crohn’s Disease (CD) is a chronic inflammatory disorder that may affect the same organs as BD, however more frequently the GI tract. Distinguish BD from CD can be very challenge due to the overlapping clinical presentation and similar morphology features on pathology biopsy specimens. Herein, we present a rare and interesting case which BD mimics IBD on the GI biopsies but with some unique findings. This is a case report of a 32-year-old, female, who first presented at ED with fatigue, weight loss, arthralgia, and erythema nodosum. One month later, patient was admitted for oral ulcers, skin rash, genital ulcers and melena. Treatment with prednisone was started at the time and further workup for BD versus IBD was initiated. Her GI biopsies show granulomatous vasculitis of esophagus and colon biopsies demonstrate overlapping features with CD.

      Short Communication Pages: 1 - 2

      Chemotherapy for Bosom Malignant Growth

      Liliana Chemello*

      Chemotherapy for bosom malignancy utilizes medications to target and obliterate bosom disease cells. These medications are generally infused straightforwardly into a vein through a needle or taken by mouth as pills.

      Review Article Pages: 1 - 3

      The Immunohistochemistry for HPV infection in High Grade Squamous cell lesions of Esophagus Diagnosed on Endoscopic Biopsies

      Purvee Agrawal,Arvind Bhake

      Background: The recent report in the literatures refers to the role of HPV in pathogenesis of esophageal cancer with geographical biases.
      There were not many reports from India where in relationship between HPV and esophageal squamous cell high grade lesions were
      analysed. Such studies are required to explore the role of HPV in esophageal Squamous cell carcinoma for its implication of prevention
      and treatment.
      Aim: The aim of study was to observe the pathogenetic relationship between high grade squamous cell lesion and HPV detected on the tissue
      biopsies by immunohistochemistry .The another objective of the study was to study relationship of HPV with grades of SCC.
      Methods: Fifty-six paraffin embedded blocks that were diagnosed as high grade squamous cell lesions were selected and the
      immunostaining for HPV was performed using mouse monoclonal Anti-Human Papillomavirus (HPV) antibodies (DAKO code M3528)
      against HPV.
      Results: The study group 56 cases endoscopic biopsies of high grade SCC showed HPV positive IHC staining in total of 12 cases (21.42%) of
      which 1 case (1.79%) was of carcinoma in-situ and 11(20%) was of invasive SCC. All the 11 cases of invasive SCC were of well differentiated
      SCC which showed positive HPV IHC staining. The p-value for the results of HPV for high grade squamous cell lesions of esophagus was
      0.0022 which was significant.
      Conclusions: There exist the association between HPV and esophagus high grade squamous cell lesions. These aspects of
      pathogenicity are required to be propped further at large sample studies to be carried out in divergent populations.
      Keywords: Squamous cell carcinoma • Human papilloma virus • Immunohistochemistry

      Case Report Pages: 1 - 3

      Tuberous sclerosis associated with pulmonary adenocarcinoma in situ: report of an unusual case and literature review

      Doaa Alayed , Assem alroumaih, Ammar cherkess alrikabi

      Our case represents a rare and perhaps unique and unusual occurrence of in situ lung adenocarcinoma in a patient who is a known case of tuberous sclerosis. We do not know, yet, if the association of lung adenocarcinoma and tuberous sclerosis is a coincidental finding or there is a casual relationship. However, further studies are warranted to highlight the nature of the linkage between the two conditions.

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Citations: 4

Journal of Surgical Pathology and Diagnosis received 4 citations as per Google Scholar report

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