Department of Medical Physiology and Biophysics, University of Seville, Seville, Spain
Opinion
Remodeling of Cellular Composition in the Rat Carotid Body′s Neurogenic Niche Elicited by Prolonged Intermittent Hypoxia
Author(s): Patricia Sobrino*
The Carotid Body (CB) stands as a prototypical organ specialized in acute oxygen (O2) sensing, orchestrating reflexive hyperventilation and heightened
cardiac output during instances of hypoxemia. The recurrence of intermittent hypoxia generates a repetitive stimulus that potentially triggers
CB overactivation, contributing to the sympathetic hyperactivity observed in sleep apnea sufferers. Despite evidence showcasing the malleability
of CB function due to chronic intermittent hypoxia (CIH), the intricate mechanisms underpinning this phenomenon remain partially understood. This
study unveils that CIH elicits a modest expansion in CB dimensions and prompts a reconfiguration of cell types within the CB structure. Notably,
this involves the mobilization of latent, immature neuroblasts, which embark upon a journey of differentiation, ultimately transforming .. Read More»
DOI:
10.37421/2684-494X.2023.8.74
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