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Journal of Inflammatory Bowel Diseases & Disorders

ISSN: 2476-1958

Open Access

Pamela B. Sylvestre

Department of Pathology, 8000 Wolf River Blvd Suite 200, Germantown, TN 38138, USA

Publications
  • Case Report   
    Sustained Histologic Remission (Complete Mucosal Healing) 12 Years after One-Time Treatment of Refractory Ulcerative Colitis with Novel Combination Therapy: A Case Report
    Author(s): Jay Pravda*, Richard Gordon and Pamela B. Sylvestre

    Ulcerative colitis is a major form of chronic inflammatory bowel disease affecting millions of individuals worldwide. It most often strikes in the prime of life, during late adolescence and early adulthood. Individuals with ulcerative colitis experience life-long reoccurring and unpredictable episodes of abdominal pain and bloody diarrhea lasting from weeks to months. This results in significant emotional and psychological burdens leading to life-long disruption of daily activities and quality of life. Environmental factors acting in concert with genetic, epigenetic, and microbiome influences are thought to trigger an immune abnormality leading to the chronic colonic inflammation observed in this condition. However, despite extensive research, a primary antecedent immune vulnerability has not been demonstrated in patients or healthy family members. Current therapy is primarily focused.. Read More»
    DOI: 10.37421/2476-1958.2020.5.132

    Abstract HTML PDF

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