Journal of Bioengineering & Biomedical Science

Department of Physiology Research, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Publications

• Research Article   
  Placental-Derived Mesenchymal Stem Cells Restore Ovarian Function and Metabolic Profile in the Rat Model for Polycystic Ovarian Syndrome
  Author(s): Mojtaba Sarvestani*, Alireza Rajabzadeh, Tahereh Mazoochi, Mansooreh Samimi, Mohsen Navar and Faezeh Moradi
  
  Introduction: Polycystic Ovary Syndrome (PCOS) is an endocrine and metabolic disturbance that affects many women worldwide and is characterized by chronic anovulation, hyperandrogenism, and ovarian dysfunction. Infertility, insulin resistance, dyslipidemia, and liver dysfunction are perturbations induced by PCOS. Mesenchymal Stem Cells (MSCs) have recently emerged as a potential therapy for metabolic disorders such as PCOS due to their anti-inflammatory, antiapoptotic, proangiogenic, and proliferative properties. Placenta-Derived Mesenchymal Stem Cells (PDMSCs) are derived from the placenta and have advantages over other sources of MSCs in terms of availability, safety, and immunomodulation. Materials and methods: In this experimental study, we assigned twenty female Wistar rats into four groups (n=5): control, sham, PCOS, and PCOS-PDMSCs. W.. Read More»
  

  Abstract PDF