Department of Pharmaceutical Sciences, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia
Mini Review
Quinazolines as Anticancer Agents Targeting Tyrosine Kinases
Author(s): Mohamed Zayed*
Cancer is a broad group of diseases that can affect any organ or tissue in the body due to abnormal cellular growth for unknown reasons. Many
existing chemotherapeutic agents are highly toxic and have low selectivity. They also contribute to the development of therapeutic resistance. As a
result, cancer treatment requires the development of targeted chemotherapeutic agents with low side effects and high selectivity. Quinazoline is a
critical scaffold that has been linked to a variety of biological activities. One of the most notable biological activities of this scaffold is its anticancer
activity. Several established anticancer quinazolines work on various molecular targets via different mechanisms. The goal of this review is
to present various aspects of medicinal chemistry such as drug design, structure-activity relationship, and mode of action of some anticance.. Read More»
DOI:
10.37421/ 2161-0444.2023.13.668
Medicinal Chemistry received 6627 citations as per Google Scholar report
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