Department of Kinesiology, University of Texas at Arlington, Arlington, USA
Opinion
Deterioration of Left Ventricular Diastolic-Systolic Coupling in Healthy Humans due to Myocardial Steatosis
Author(s): Michael Oneglia*
A growing body of evidence points towards the involvement of myocardial steatosis in the development of left ventricular diastolic dysfunction,
although conclusive proof in humans is hampered by complicating coexisting conditions. To address this, we employed a 48-hour food restriction
protocol to induce an acute elevation in Myocardial Triglyceride (mTG) content quantified using 1H magnetic resonance spectroscopy in a cohort of
27 young and healthy volunteers (comprising 13 men and 14 women). The results of the fasting regimen exhibited a remarkable over threefold rise
in mTG content (P<0.001). Interestingly, the early diastolic circumferential strain rate (CSRd), a marker of diastolic function, remained unaffected
following the 48-hour fasting intervention. However, a noteworthy elevation in systolic circumferential strain rate was observed (P<0.001), indic.. Read More»
DOI:
10.37421/2684-494X.2023.8.67
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