University of Isfahan, Iran
Value Added Abstracts
Effect of Lactobacilli on spatial memory and hippocampal APP gene
expression in the rat model of Alzheimer’s disease
Author(s): Maryam Noorbakhshnia
Background and Aim: Alzheimer's disease is a
neurodegenerative disorder that is associated with progressive
degeneration of hippocampal and cortical neurons that leads to
memory loss. Overexpression and production of amyloid-beta
(Aβ) is the most significant factor in the pathogenesis of
Alzheimer's disease. Recent studies have found a role for the
gut microbiota in the gut-brain axis, which can affect cognitive
and memory abilities. The purpose of this study was to
investigate the effect of lactobacilli on the spatial memory and
expression of APP gene in the hippocampus of Aluminum
chloride (AlCl3) induced animal model of Alzheimer's disease.
Methods: Adult male wistar rats weighing (240–250 g) were
used. Animals received either saline, Alcl3 (100 mg/kg),
lactobaci.. Read More»
Neurological Disorders received 1253 citations as per Google Scholar report
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