Journal of Genetics and DNA Research

ISSN: 2684-6039

Open Access

Mario Ventura

Department of Genome Sciences, University of Bari, Bari BA, Italy

  • Mini Review   
    CRISPR/Cas9 Gene Editing in Cancer: Current Applications and Future Prospects
    Author(s): Mario Ventura*

    In prokaryotes, the clustered regularly interspaced short palindromic repeats (CRISPR) system provides adaptive immunity against plasmids and phages. This system inspired the development of the CRISPR/Cas9 genome editing system, which is a powerful genome engineering tool. The CRISPR/Cas9 technique has been used to investigate the functions of cancer-related genes, establish tumor-bearing animal models and probe drug targets, greatly increasing our understanding of cancer genomics. In this paper, we examine the current state of CRISPR/Cas9 gene editing technology in oncological research. We begin by explaining the fundamental principles of CRISPR/Cas9 gene editing before introducing several new CRISPR-based gene editing modes. The rapid progress of CRISPR screening in revealing tumorigenesis, metastasis and drug resistance mechanisms is then described... Read More»
    DOI: 10.37421/2684-6039.2022.6.134

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