Neurological Disorders

Department of Medicine, National Yang-Ming Chiao-Tung University Hospital, Taiwan

Publications

• Research Article   
  Rapid Assessments to Differentiate Dementia Using Plasma Biomarkers in Primary Care
  Author(s): Ping-Huang Tsai*, Li-Cho Hsu, Hsuan-Ming Tsao, Shieh-Yueh Yang and Kuen-Lin Chen
  
  Introduction: The aging of society has increased the incidence of dementia, which is more common among older individuals. Older individuals are typically cared for by primary care providers in hospitals. However, more than 60% of patients with early-stage dementia are unrecognized in primary care. Several groups have developed dementia screening tools for primary care purposes. In this work, assessments based on plasma biomarkers for differentiating among various types of dementia were developed for primary care applications. Methods: Forty-six patients with very mild dementia (VMD) or mild cognitive impairment (MCI), fifty patients with Alzheimer’s disease (AD), and four patients with non-AD dementia were enrolled. Plasma amyloid-beta 1–40 (Aβ1–40), Aβ1–42, total Tau (T-Tau), and phosphorylated Tau (p-Tau181) were assayed using immunomagnetic reducti.. Read More»
  DOI: 10.37421/2329-6895.2021.9.443

  Abstract HTML PDF